skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Advanced proteomic liquid chromatography

Abstract

Liquid chromatography coupled with mass spectrometry is the predominant platform used to analyze proteomics samples consisting of large numbers of proteins and their proteolytic products (e.g., truncated polypeptides) and spanning a wide range of relative concentrations. This review provides an overview of advanced capillary liquid chromatography techniques and methodologies that greatly improve separation resolving power and proteomics analysis coverage, sensitivity, and throughput.

Authors:
; ;
Publication Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)
Sponsoring Org.:
USDOE
OSTI Identifier:
1052523
Report Number(s):
PNNL-SA-86948
40072; 46206; 400412000
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Journal Article
Journal Name:
Journal of Chromatography A, 1261:78-90
Additional Journal Information:
Journal Name: Journal of Chromatography A, 1261:78-90
Country of Publication:
United States
Language:
English
Subject:
Environmental Molecular Sciences Laboratory

Citation Formats

Xie, Fang, Smith, Richard D., and Shen, Yufeng. Advanced proteomic liquid chromatography. United States: N. p., 2012. Web. doi:10.1016/j.chroma.2012.06.098.
Xie, Fang, Smith, Richard D., & Shen, Yufeng. Advanced proteomic liquid chromatography. United States. doi:10.1016/j.chroma.2012.06.098.
Xie, Fang, Smith, Richard D., and Shen, Yufeng. Fri . "Advanced proteomic liquid chromatography". United States. doi:10.1016/j.chroma.2012.06.098.
@article{osti_1052523,
title = {Advanced proteomic liquid chromatography},
author = {Xie, Fang and Smith, Richard D. and Shen, Yufeng},
abstractNote = {Liquid chromatography coupled with mass spectrometry is the predominant platform used to analyze proteomics samples consisting of large numbers of proteins and their proteolytic products (e.g., truncated polypeptides) and spanning a wide range of relative concentrations. This review provides an overview of advanced capillary liquid chromatography techniques and methodologies that greatly improve separation resolving power and proteomics analysis coverage, sensitivity, and throughput.},
doi = {10.1016/j.chroma.2012.06.098},
journal = {Journal of Chromatography A, 1261:78-90},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {10}
}