skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Advanced proteomic liquid chromatography

Journal Article · · Journal of Chromatography A, 1261:78-90

Liquid chromatography coupled with mass spectrometry is the predominant platform used to analyze proteomics samples consisting of large numbers of proteins and their proteolytic products (e.g., truncated polypeptides) and spanning a wide range of relative concentrations. This review provides an overview of advanced capillary liquid chromatography techniques and methodologies that greatly improve separation resolving power and proteomics analysis coverage, sensitivity, and throughput.

Research Organization:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
OSTI ID:
1052523
Report Number(s):
PNNL-SA-86948; 40072; 46206; 400412000
Journal Information:
Journal of Chromatography A, 1261:78-90, Journal Name: Journal of Chromatography A, 1261:78-90
Country of Publication:
United States
Language:
English