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Title: Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

Abstract

Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Idaho National Lab. (INL), Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1049381
Report Number(s):
INL/JOU-12-26991
Journal ID: ISSN 0250-7005; ANTRD4; TRN: US201218%%1446
DOE Contract Number:  
DE-AC07-05ID14517
Resource Type:
Journal Article
Journal Name:
Anticancer Research
Additional Journal Information:
Journal Volume: 32; Journal Issue: 7; Journal ID: ISSN 0250-7005
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; BLOOD; BLOOD VESSELS; DELIVERY; DRUGS; DYES; EVANS BLUE; HAMSTERS; HEAD; IN VIVO; MORPHOLOGY; NECK; NEOPLASMS; ORAL CAVITY; OXYGEN; REDUCTION; THERAPY; blood vessel normalization; hamster cheek pouch oral cancer model; oral cancer; thalidomide

Citation Formats

Molinari, Ana J, Aromando, Romina F, Itoiz, Maria E, Garabalino, Marcela A, Hughes, Andrea Monti, Heber, Elisa M, Pozzi, Emiliano C. C., Nigg, David W, Trivillin, Veronica A, and Schwint, Amanda E. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies. United States: N. p., 2012. Web.
Molinari, Ana J, Aromando, Romina F, Itoiz, Maria E, Garabalino, Marcela A, Hughes, Andrea Monti, Heber, Elisa M, Pozzi, Emiliano C. C., Nigg, David W, Trivillin, Veronica A, & Schwint, Amanda E. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies. United States.
Molinari, Ana J, Aromando, Romina F, Itoiz, Maria E, Garabalino, Marcela A, Hughes, Andrea Monti, Heber, Elisa M, Pozzi, Emiliano C. C., Nigg, David W, Trivillin, Veronica A, and Schwint, Amanda E. 2012. "Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies". United States.
@article{osti_1049381,
title = {Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies},
author = {Molinari, Ana J and Aromando, Romina F and Itoiz, Maria E and Garabalino, Marcela A and Hughes, Andrea Monti and Heber, Elisa M and Pozzi, Emiliano C. C. and Nigg, David W and Trivillin, Veronica A and Schwint, Amanda E},
abstractNote = {Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.},
doi = {},
url = {https://www.osti.gov/biblio/1049381}, journal = {Anticancer Research},
issn = {0250-7005},
number = 7,
volume = 32,
place = {United States},
year = {Sun Jul 01 00:00:00 EDT 2012},
month = {Sun Jul 01 00:00:00 EDT 2012}
}