skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Influence of lipid membranes rigidity on properties of supporting polymer

Abstract

The motivation of this study is: (1) Controllable release of cultured cell sheets - (a) NIPAAm is non-toxic and collapsed at physiological Temp, (b) good platform for cell adherence and growth, (c) below polymer transition temp, cultured sheets are released, (d) hydration of matrix possible cause of cell attachment/detachment, (e) need for understanding hydration of underlying support; (2) Matrix elasticity plays an important role in cell lineage specification - (a) matrices of known stiffness are utilized as supports to understand physical effect of in-vivo tissue microenvironment for therapeutic uses of stem cells, (b) it is believed that stem cells 'sense' the elasticity and transduce the information into morphological changes, (c) Imperative to consider the changes induced in matrix as a result of immobilized cells.

Authors:
 [1];  [1];  [2]
  1. Los Alamos National Laboratory
  2. Intel, Pheonix, AZ
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
Basic Energy and Sciences
OSTI Identifier:
1044105
Report Number(s):
LA-UR-12-22295
TRN: US201214%%308
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Conference
Resource Relation:
Conference: American conference on neutron scattering (ACNS) 2012 ; 2012-06-24 - 2012-06-28 ; Washington DC, District Of Columbia, United States
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; ELASTICITY; FLEXIBILITY; HYDRATION; IMMOBILIZED CELLS; IN VIVO; LIPIDS; MATRICES; MEMBRANES; MORPHOLOGICAL CHANGES; NEUTRONS; POLYMERS; SCATTERING; SPECIFICATIONS; STEM CELLS; THERAPEUTIC USES

Citation Formats

Majewski, Jaroslaw, Singh, Saurabh, and Dubey, Manish. Influence of lipid membranes rigidity on properties of supporting polymer. United States: N. p., 2012. Web.
Majewski, Jaroslaw, Singh, Saurabh, & Dubey, Manish. Influence of lipid membranes rigidity on properties of supporting polymer. United States.
Majewski, Jaroslaw, Singh, Saurabh, and Dubey, Manish. Mon . "Influence of lipid membranes rigidity on properties of supporting polymer". United States. https://www.osti.gov/servlets/purl/1044105.
@article{osti_1044105,
title = {Influence of lipid membranes rigidity on properties of supporting polymer},
author = {Majewski, Jaroslaw and Singh, Saurabh and Dubey, Manish},
abstractNote = {The motivation of this study is: (1) Controllable release of cultured cell sheets - (a) NIPAAm is non-toxic and collapsed at physiological Temp, (b) good platform for cell adherence and growth, (c) below polymer transition temp, cultured sheets are released, (d) hydration of matrix possible cause of cell attachment/detachment, (e) need for understanding hydration of underlying support; (2) Matrix elasticity plays an important role in cell lineage specification - (a) matrices of known stiffness are utilized as supports to understand physical effect of in-vivo tissue microenvironment for therapeutic uses of stem cells, (b) it is believed that stem cells 'sense' the elasticity and transduce the information into morphological changes, (c) Imperative to consider the changes induced in matrix as a result of immobilized cells.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {6}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: