Influence of lipid membranes rigidity on properties of supporting polymer
- Los Alamos National Laboratory
- Intel, Pheonix, AZ
The motivation of this study is: (1) Controllable release of cultured cell sheets - (a) NIPAAm is non-toxic and collapsed at physiological Temp, (b) good platform for cell adherence and growth, (c) below polymer transition temp, cultured sheets are released, (d) hydration of matrix possible cause of cell attachment/detachment, (e) need for understanding hydration of underlying support; (2) Matrix elasticity plays an important role in cell lineage specification - (a) matrices of known stiffness are utilized as supports to understand physical effect of in-vivo tissue microenvironment for therapeutic uses of stem cells, (b) it is believed that stem cells 'sense' the elasticity and transduce the information into morphological changes, (c) Imperative to consider the changes induced in matrix as a result of immobilized cells.
- Research Organization:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Organization:
- Basic Energy and Sciences
- DOE Contract Number:
- AC52-06NA25396
- OSTI ID:
- 1044105
- Report Number(s):
- LA-UR-12-22295; TRN: US201214%%308
- Resource Relation:
- Conference: American conference on neutron scattering (ACNS) 2012 ; 2012-06-24 - 2012-06-28 ; Washington DC, District Of Columbia, United States
- Country of Publication:
- United States
- Language:
- English
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