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Title: Insights into Cdc13 Dependent Telomere Length Regulation

Abstract

Cdc13 is a single stranded telomere binding protein that specifically localizes to the telomere ends of budding yeasts and is essential for cell viability. It caps the ends of chromosomes thus preventing chromosome end-to-end fusions and exonucleolytic degradation, events that could lead to genomic instability and senescence, the hallmark of aging. Cdc13 is also involved in telomere length regulation by recruiting or preventing access of telomerase to the telomeric overhang. Recruitment of telomerase to the telomeres for G-strand extension is required for continuous cell division, while preventing its access to the telomeres through capping the chromosome ends prevents mitotic events that could lead to cell immortality, the hall mark of carcinogenesis. Cdc13 and its putative homologues human CTC1 and POT1 are therefore key to many biological processes directly associated with life extension and cancer prevention and can be viewed as an ideal target for cancer and age related therapies.

Authors:
;
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE SC OFFICE OF SCIENCE (SC)
OSTI Identifier:
1042297
Report Number(s):
BNL-97975-2012-JA
TRN: US201212%%708
DOE Contract Number:  
DE-AC02-98CH10886
Resource Type:
Journal Article
Journal Name:
Aging
Additional Journal Information:
Journal Volume: 2; Journal Issue: 10
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; AGING; CARCINOGENESIS; CELL DIVISION; CHROMOSOMES; HUMAN POPULATIONS; INSTABILITY; LENGTH; NEOPLASMS; PROTEINS; REGULATIONS; TARGETS; TELOMERES; VIABILITY; YEASTS

Citation Formats

Mason, M, and Skordalakes, E. Insights into Cdc13 Dependent Telomere Length Regulation. United States: N. p., 2011. Web.
Mason, M, & Skordalakes, E. Insights into Cdc13 Dependent Telomere Length Regulation. United States.
Mason, M, and Skordalakes, E. 2011. "Insights into Cdc13 Dependent Telomere Length Regulation". United States.
@article{osti_1042297,
title = {Insights into Cdc13 Dependent Telomere Length Regulation},
author = {Mason, M and Skordalakes, E},
abstractNote = {Cdc13 is a single stranded telomere binding protein that specifically localizes to the telomere ends of budding yeasts and is essential for cell viability. It caps the ends of chromosomes thus preventing chromosome end-to-end fusions and exonucleolytic degradation, events that could lead to genomic instability and senescence, the hallmark of aging. Cdc13 is also involved in telomere length regulation by recruiting or preventing access of telomerase to the telomeric overhang. Recruitment of telomerase to the telomeres for G-strand extension is required for continuous cell division, while preventing its access to the telomeres through capping the chromosome ends prevents mitotic events that could lead to cell immortality, the hall mark of carcinogenesis. Cdc13 and its putative homologues human CTC1 and POT1 are therefore key to many biological processes directly associated with life extension and cancer prevention and can be viewed as an ideal target for cancer and age related therapies.},
doi = {},
url = {https://www.osti.gov/biblio/1042297}, journal = {Aging},
number = 10,
volume = 2,
place = {United States},
year = {Sat Dec 31 00:00:00 EST 2011},
month = {Sat Dec 31 00:00:00 EST 2011}
}