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Title: Single-Shot Femtosecond X-ray Diffraction from Randomly Oriented Ellipsoidal Nanoparticles

Abstract

Coherent diffractive imaging of single particles using the single-shot 'diffract and destroy' approach with an x-ray free electron laser (FEL) was recently demonstrated. A high-resolution low-noise coherent diffraction pattern, representative of the object before it turns into a plasma and explodes, results from the interaction of the FEL with the particle. Iterative phase retrieval algorithms are used to reconstruct two-dimensional projection images of the object from the recorded intensities alone. Here we describe the first single-shot diffraction data set that mimics the data proposed for obtaining 3D structure from identical particles. Ellipsoidal iron oxide nanoparticles (250 nm x 50 nm) were aerosolized and injected through an aerodynamic lens stack into a soft x-ray FEL. Particle orientation was not controlled with this injection method. We observed that, at the instant the x-ray pulse interacts with the particle, a snapshot of the particle's orientation is encoded in the diffraction pattern. The results give credence to one of the technical concepts of imaging individual nanometer and subnanometer-sized objects such as single molecules or larger clusters of molecules using hard x-ray FELs and will be used to help develop robust algorithms for determining particle orientations and 3D structure.

Authors:
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Publication Date:
Research Org.:
SLAC National Accelerator Lab., Menlo Park, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1039551
Report Number(s):
SLAC-REPRINT-2012-035
Journal ID: ISSN 1098-4402; TRN: US1202174
DOE Contract Number:  
AC02-76SF00515
Resource Type:
Journal Article
Journal Name:
Physical Review Special Topics - Accelerators and Beams
Additional Journal Information:
Journal Volume: 13; Journal Issue: 9; Journal ID: ISSN 1098-4402
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; AERODYNAMICS; ALGORITHMS; DIFFRACTION; FREE ELECTRON LASERS; IRON OXIDES; ORIENTATION; PLASMA; X-RAY DIFFRACTION; Accelerators,XFEL

Citation Formats

Bogan, M J, /SLAC, Boutet, S, /SLAC, Barty, A, /LLNL, Livermore /DESY, Benner, W H, Frank, M, /LLNL, Livermore, Lomb, L, Shoeman, R, /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg, Starodub, D, /SLAC, Seibert, M M, /Uppsala U., Hau-Riege, S P, Woods, B, /LLNL, Livermore, Decorwin-Martin, P, /SLAC, Bajt, S, /DESY, Schulz, J, /DESY, Rohner, U, /LLNL, Livermore /Unlisted, CH, Iwan, B, Timneanu, N, /Uppsala U., Marchesini, S, /LBL, Berkeley, Schlichting, I, /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg, Hajdu, J, /Uppsala U., Chapman, H N, and /DESY /Hamburg U., Inst. Theor. Phys. II. Single-Shot Femtosecond X-ray Diffraction from Randomly Oriented Ellipsoidal Nanoparticles. United States: N. p., 2012. Web.
Bogan, M J, /SLAC, Boutet, S, /SLAC, Barty, A, /LLNL, Livermore /DESY, Benner, W H, Frank, M, /LLNL, Livermore, Lomb, L, Shoeman, R, /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg, Starodub, D, /SLAC, Seibert, M M, /Uppsala U., Hau-Riege, S P, Woods, B, /LLNL, Livermore, Decorwin-Martin, P, /SLAC, Bajt, S, /DESY, Schulz, J, /DESY, Rohner, U, /LLNL, Livermore /Unlisted, CH, Iwan, B, Timneanu, N, /Uppsala U., Marchesini, S, /LBL, Berkeley, Schlichting, I, /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg, Hajdu, J, /Uppsala U., Chapman, H N, & /DESY /Hamburg U., Inst. Theor. Phys. II. Single-Shot Femtosecond X-ray Diffraction from Randomly Oriented Ellipsoidal Nanoparticles. United States.
Bogan, M J, /SLAC, Boutet, S, /SLAC, Barty, A, /LLNL, Livermore /DESY, Benner, W H, Frank, M, /LLNL, Livermore, Lomb, L, Shoeman, R, /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg, Starodub, D, /SLAC, Seibert, M M, /Uppsala U., Hau-Riege, S P, Woods, B, /LLNL, Livermore, Decorwin-Martin, P, /SLAC, Bajt, S, /DESY, Schulz, J, /DESY, Rohner, U, /LLNL, Livermore /Unlisted, CH, Iwan, B, Timneanu, N, /Uppsala U., Marchesini, S, /LBL, Berkeley, Schlichting, I, /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg, Hajdu, J, /Uppsala U., Chapman, H N, and /DESY /Hamburg U., Inst. Theor. Phys. II. Wed . "Single-Shot Femtosecond X-ray Diffraction from Randomly Oriented Ellipsoidal Nanoparticles". United States.
@article{osti_1039551,
title = {Single-Shot Femtosecond X-ray Diffraction from Randomly Oriented Ellipsoidal Nanoparticles},
author = {Bogan, M J and /SLAC and Boutet, S and /SLAC and Barty, A and /LLNL, Livermore /DESY and Benner, W H and Frank, M and /LLNL, Livermore and Lomb, L and Shoeman, R and /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg and Starodub, D and /SLAC and Seibert, M M and /Uppsala U. and Hau-Riege, S P and Woods, B and /LLNL, Livermore and Decorwin-Martin, P and /SLAC and Bajt, S and /DESY and Schulz, J and /DESY and Rohner, U and /LLNL, Livermore /Unlisted, CH and Iwan, B and Timneanu, N and /Uppsala U. and Marchesini, S and /LBL, Berkeley and Schlichting, I and /Heidelberg, Max Planck Inst. Med. Res. /CFEL, Hamburg and Hajdu, J and /Uppsala U. and Chapman, H N and /DESY /Hamburg U., Inst. Theor. Phys. II},
abstractNote = {Coherent diffractive imaging of single particles using the single-shot 'diffract and destroy' approach with an x-ray free electron laser (FEL) was recently demonstrated. A high-resolution low-noise coherent diffraction pattern, representative of the object before it turns into a plasma and explodes, results from the interaction of the FEL with the particle. Iterative phase retrieval algorithms are used to reconstruct two-dimensional projection images of the object from the recorded intensities alone. Here we describe the first single-shot diffraction data set that mimics the data proposed for obtaining 3D structure from identical particles. Ellipsoidal iron oxide nanoparticles (250 nm x 50 nm) were aerosolized and injected through an aerodynamic lens stack into a soft x-ray FEL. Particle orientation was not controlled with this injection method. We observed that, at the instant the x-ray pulse interacts with the particle, a snapshot of the particle's orientation is encoded in the diffraction pattern. The results give credence to one of the technical concepts of imaging individual nanometer and subnanometer-sized objects such as single molecules or larger clusters of molecules using hard x-ray FELs and will be used to help develop robust algorithms for determining particle orientations and 3D structure.},
doi = {},
journal = {Physical Review Special Topics - Accelerators and Beams},
issn = {1098-4402},
number = 9,
volume = 13,
place = {United States},
year = {2012},
month = {4}
}