Site-specific incorporation of redox active amino acids into proteins
Abstract
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
- Inventors:
-
- San Diego, CA
- La Jolla, CA
- Publication Date:
- Research Org.:
- The Scripps Research Institute (LaJolla, CA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1036985
- Patent Number(s):
- 8,114,654
- Application Number:
- 12/806,751
- Assignee:
- The Scripps Research Institute (LaJolla, CA)
- DOE Contract Number:
- FG03-00ER45812
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Alfonta, Lital, Schultz, Peter G, and Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States: N. p., 2012.
Web.
Alfonta, Lital, Schultz, Peter G, & Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States.
Alfonta, Lital, Schultz, Peter G, and Zhang, Zhiwen. 2012.
"Site-specific incorporation of redox active amino acids into proteins". United States. https://www.osti.gov/servlets/purl/1036985.
@article{osti_1036985,
title = {Site-specific incorporation of redox active amino acids into proteins},
author = {Alfonta, Lital and Schultz, Peter G and Zhang, Zhiwen},
abstractNote = {Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.},
doi = {},
url = {https://www.osti.gov/biblio/1036985},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 14 00:00:00 EST 2012},
month = {Tue Feb 14 00:00:00 EST 2012}
}
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