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Title: Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.

Abstract

The ultrastructural response to applied loads governs the post-yield deformation and failure behavior of bone, and is correlated with bone fragility fractures. Combining a novel progressive loading protocol and synchrotron X-ray scattering techniques, this study investigated the correlation of the local deformation (i.e., internal strains of the mineral and collagen phases) with the bulk mechanical behavior of bone. The results indicated that the internal strains of the longitudinally oriented collagen fibrils and mineral crystals increased almost linearly with respect to the macroscopic strain prior to yielding, but markedly decreased first and then gradually leveled off after yielding. Similar changes were also observed in the applied stress before and after yielding of bone. However, the collagen to mineral strain ratio remained nearly constant throughout the loading process. In addition, the internal strains of longitudinal mineral and collagen phases did not exhibit a linear relationship with either the modulus loss or the plastic deformation of bulk bone tissue. Finally, the time-dependent response of local deformation in the mineral phase was observed after yielding. Based on the results, we speculate that the mineral crystals and collagen fibrils aligned with the loading axis only partially explain the post-yield deformation, suggesting that shear deformation involvingmore » obliquely oriented crystals and fibrils (off axis) is dominant mechanism of yielding for human cortical bone in compression.« less

Authors:
; ;  [1];  [2]
  1. (X-Ray Science Division)
  2. (
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
National Institutes of Health (NIH)
OSTI Identifier:
1036942
Report Number(s):
ANL/XSD/JA-72660
Journal ID: ISSN 0021-9290; TRN: US201206%%681
DOE Contract Number:  
DE-AC02-06CH11357
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Biomechanics; Journal Volume: 44; Journal Issue: 4
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; BONE TISSUES; COLLAGEN; COMPRESSION; DEFORMATION; FRACTURES; PLASTICS; SCATTERING; SHEAR; STRAINS; SYNCHROTRONS

Citation Formats

Dong, X.N., Almer, J.D., Wang, X., and University of Texas). Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.. United States: N. p., 2011. Web. doi:10.1016/j.jbiomech.2010.11.003.
Dong, X.N., Almer, J.D., Wang, X., & University of Texas). Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.. United States. doi:10.1016/j.jbiomech.2010.11.003.
Dong, X.N., Almer, J.D., Wang, X., and University of Texas). Thu . "Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.". United States. doi:10.1016/j.jbiomech.2010.11.003.
@article{osti_1036942,
title = {Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.},
author = {Dong, X.N. and Almer, J.D. and Wang, X. and University of Texas)},
abstractNote = {The ultrastructural response to applied loads governs the post-yield deformation and failure behavior of bone, and is correlated with bone fragility fractures. Combining a novel progressive loading protocol and synchrotron X-ray scattering techniques, this study investigated the correlation of the local deformation (i.e., internal strains of the mineral and collagen phases) with the bulk mechanical behavior of bone. The results indicated that the internal strains of the longitudinally oriented collagen fibrils and mineral crystals increased almost linearly with respect to the macroscopic strain prior to yielding, but markedly decreased first and then gradually leveled off after yielding. Similar changes were also observed in the applied stress before and after yielding of bone. However, the collagen to mineral strain ratio remained nearly constant throughout the loading process. In addition, the internal strains of longitudinal mineral and collagen phases did not exhibit a linear relationship with either the modulus loss or the plastic deformation of bulk bone tissue. Finally, the time-dependent response of local deformation in the mineral phase was observed after yielding. Based on the results, we speculate that the mineral crystals and collagen fibrils aligned with the loading axis only partially explain the post-yield deformation, suggesting that shear deformation involving obliquely oriented crystals and fibrils (off axis) is dominant mechanism of yielding for human cortical bone in compression.},
doi = {10.1016/j.jbiomech.2010.11.003},
journal = {Journal of Biomechanics},
number = 4,
volume = 44,
place = {United States},
year = {Thu Feb 24 00:00:00 EST 2011},
month = {Thu Feb 24 00:00:00 EST 2011}
}