"Sequential” Boron Neutron Capture Therapy (BNCT): A Novel Approach to BNCT for the Treatment of Oral Cancer in the Hamster Cheek Pouch Model

Journal Article · Fri Apr 01 00:00:00 EDT 2011 · Radiation Research

DOI:https://doi.org/10.1667/RR2148.1· OSTI ID:1036262

Molinari, Ana J; Hughes, Andrea Monti; Heber, Elisa M; Garabalino, Marcela A; Trivillin, Veronica A; Schwint, Amanda E; Pozzi, Emiliano C. C.; Itoiz, Maria E; Thorp, Silvia I; Aromando, Romina F; Nigg, David W; Quintana, Jorge; Santa Cruz, Gustavo A

Boron Neutron Capture Therapy (BNCT) is a binary treatment modality that involves the selective accumulation of 10B carriers in tumors followed by irradiation with a thermal or epithermal neutron beam. The minor abundance stable isotope of boron, 10B, interacts with low energy (thermal) neutrons to produce high linear energy transfer (LET) a-particles and 7Li ions. These disintegration products are known to have a high relative biological effectiveness (RBE). Their short range (<10 {micro}m) would limit the damage to cells containing 10B (1,2). Thus, BNCT would target tumor tissue selectively, sparing normal tissue. Clinical trials of BNCT for the treatment of glioblastoma multiforme and/or melanoma and, more recently, head and neck tumors and liver metastases, using boronophenylalanine (BPA) or sodium mercaptoundecahydrododecaborane (BSH) as the 10B carriers, have been performed or are underway in Argentina, Japan, the US and Europe (e.g. 3-8). To date, the clinical results have shown a potential, albeit inconclusive, therapeutic advantage for this technique. Contributory translational studies have been carried out employing a variety of experimental models based on the implantation of tumor cells in normal tissue (e.g. 5).

• Research Organization: Idaho National Lab. (INL), Idaho Falls, ID (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: DE-AC07-05ID14517
• OSTI ID: 1036262
• Report Number(s): INL/JOU-11-21122; RAREAE; TRN: US1201335
• Journal Information: Radiation Research, Vol. 175, Issue 4; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
62 RADIOLOGY AND NUCLEAR MEDICINE
ABUNDANCE
BORON
CLINICAL TRIALS
EPITHERMAL NEUTRONS
GLIOMAS
HAMSTERS
IRRADIATION
LET
LIVER
MELANOMAS
METASTASES
NEOPLASMS
NEUTRON CAPTURE THERAPY
NEUTRONS
RBE
SODIUM
STABLE ISOTOPES
TARGETS
TUMOR CELLS
Boron Neutron Capture Therapy (BNCT)
oral cancer