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Title: Statistical Characterization and Segmentation of Drusen in Fundus Images

Abstract

Age related Macular Degeneration (AMD) is a disease of the retina associated with aging. AMD progression in patients is characterized by drusen, pigmentation changes, and geographic atrophy, which can be seen using fundus imagery. The level of AMD is characterized by standard scaling methods, which can be somewhat subjective in practice. In this work we propose a statistical image processing approach to segment drusen with the ultimate goal of characterizing the AMD progression in a data set of longitudinal images. The method characterizes retinal structures with a statistical model of the colors in the retina image. When comparing the segmentation results of the method between longitudinal images with known AMD progression and those without, the method detects progression in our longitudinal data set with an area under the receiver operating characteristics curve of 0.99.

Authors:
 [1];  [1];  [1];  [1];  [2];  [1];  [1];  [2]
  1. ORNL
  2. University of Tennessee, Knoxville (UTK)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE; Work for Others (WFO)
OSTI Identifier:
1035144
DOE Contract Number:
DE-AC05-00OR22725
Resource Type:
Conference
Resource Relation:
Conference: 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 11), Boston, MA, USA, 20110830, 20110903
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; AGING; ATROPHY; BIOLOGY; DISEASES; IMAGE PROCESSING; MEDICINE; PATIENTS; RETINA; STATISTICAL MODELS

Citation Formats

Santos-Villalobos, Hector J, Karnowski, Thomas Paul, Aykac, Deniz, Giancardo, Luca, Li, Yaquin, Nichols, Trent L, Tobin Jr, Kenneth William, and Chaum, Edward. Statistical Characterization and Segmentation of Drusen in Fundus Images. United States: N. p., 2011. Web.
Santos-Villalobos, Hector J, Karnowski, Thomas Paul, Aykac, Deniz, Giancardo, Luca, Li, Yaquin, Nichols, Trent L, Tobin Jr, Kenneth William, & Chaum, Edward. Statistical Characterization and Segmentation of Drusen in Fundus Images. United States.
Santos-Villalobos, Hector J, Karnowski, Thomas Paul, Aykac, Deniz, Giancardo, Luca, Li, Yaquin, Nichols, Trent L, Tobin Jr, Kenneth William, and Chaum, Edward. Sat . "Statistical Characterization and Segmentation of Drusen in Fundus Images". United States. doi:.
@article{osti_1035144,
title = {Statistical Characterization and Segmentation of Drusen in Fundus Images},
author = {Santos-Villalobos, Hector J and Karnowski, Thomas Paul and Aykac, Deniz and Giancardo, Luca and Li, Yaquin and Nichols, Trent L and Tobin Jr, Kenneth William and Chaum, Edward},
abstractNote = {Age related Macular Degeneration (AMD) is a disease of the retina associated with aging. AMD progression in patients is characterized by drusen, pigmentation changes, and geographic atrophy, which can be seen using fundus imagery. The level of AMD is characterized by standard scaling methods, which can be somewhat subjective in practice. In this work we propose a statistical image processing approach to segment drusen with the ultimate goal of characterizing the AMD progression in a data set of longitudinal images. The method characterizes retinal structures with a statistical model of the colors in the retina image. When comparing the segmentation results of the method between longitudinal images with known AMD progression and those without, the method detects progression in our longitudinal data set with an area under the receiver operating characteristics curve of 0.99.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 2011},
month = {Sat Jan 01 00:00:00 EST 2011}
}

Conference:
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