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Title: Positron emission tomography probes for imaging immune activation and selected cancers

Abstract

Compounds for use as PET probes and methods for synthesizing and using these, comprising [.sup.18F]D-FAC and other cytosine and adenosine analogs.

Inventors:
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Los Angeles, CA
Publication Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1034633
Patent Number(s):
8,101,740
Application Number:
12/234,478
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
FG02-06ER64249
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Radu, Caius G, Witte, Owen N, Nair-Gill, Evan David, Satyamurthy, Nagichettiar, Shu, Chengyi J, and Czernin, Johannes. Positron emission tomography probes for imaging immune activation and selected cancers. United States: N. p., 2012. Web.
Radu, Caius G, Witte, Owen N, Nair-Gill, Evan David, Satyamurthy, Nagichettiar, Shu, Chengyi J, & Czernin, Johannes. Positron emission tomography probes for imaging immune activation and selected cancers. United States.
Radu, Caius G, Witte, Owen N, Nair-Gill, Evan David, Satyamurthy, Nagichettiar, Shu, Chengyi J, and Czernin, Johannes. 2012. "Positron emission tomography probes for imaging immune activation and selected cancers". United States. https://www.osti.gov/servlets/purl/1034633.
@article{osti_1034633,
title = {Positron emission tomography probes for imaging immune activation and selected cancers},
author = {Radu, Caius G and Witte, Owen N and Nair-Gill, Evan David and Satyamurthy, Nagichettiar and Shu, Chengyi J and Czernin, Johannes},
abstractNote = {Compounds for use as PET probes and methods for synthesizing and using these, comprising [.sup.18F]D-FAC and other cytosine and adenosine analogs.},
doi = {},
url = {https://www.osti.gov/biblio/1034633}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 24 00:00:00 EST 2012},
month = {Tue Jan 24 00:00:00 EST 2012}
}

Works referenced in this record:

A simplified synthesis of 18F-labelled cytosine- and uracil-nucleosides
journal, January 1986

  • Visser, Gerard W. M.; Noordhuis, Paul; Zwaagstra, Oene
  • International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, Vol. 37, Issue 10
  • https://doi.org/10.1016/0883-2889(86)90049-3

A method of image registration for small animal, multi-modality imaging
journal, January 2006


The Role of Deoxycytidine Kinase in Gemcitabine Cytotoxicity
book, January 2002


Identification of in Vivo Phosphorylation Sites on Human Deoxycytidine Kinase : ROLE OF SER-74 IN THE CONTROL OF ENZYME ACTIVITY
journal, December 2005


A general synthesis of 2?-deoxy-2?-[18F]fluoro-1-?-D-arabinofuranosyluracil and its 5-substituted nucleosides
journal, January 2003

  • Alauddin, Mian M.; Conti, Peter S.; Fissekis, John D.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, Issue 4
  • https://doi.org/10.1002/jlcr.637

Monitoring the Antitumor Response of Naive and Memory CD8 T Cells in RAG1 −/− Mice by Positron-Emission Tomography
journal, March 2006


Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
journal, January 2003

  • Alauddin, Mian M.; Fissekis, John D.; Conti, Peter S.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, Issue 9, p. 805-814
  • https://doi.org/10.1002/jlcr.712

Kinetics of inflammation and sarcoma cell development in primary moloney sarcoma-virus-induced tumors
journal, February 1981


Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes
journal, March 2003


Cytotoxic activity of gemcitabine and correlation with expression profile of drug-related genes in human lymphoid cells
journal, April 2007


Review of recent studies on resistance to cytotoxic deoxynucleoside analogues
journal, December 2007


Visualization of a primary anti-tumor immune response by positron emission tomography
journal, November 2005


Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes
journal, June 2007


AMIDE: A Free Software Tool for Multimodality Medical Image Analysis
journal, July 2003


Adoptive immunotherapy for cancer: building on success
journal, April 2006


Regulation of the Oncogenic Activity of BCR-ABL by a Tightly Bound Substrate Protein RIN1
journal, June 1997


Synthesis of [18F]-labeled 2?-deoxy-2?-fluoro-5-methyl-1-?-D-arabinofuranosyluracil ([18F]-FMAU)
journal, January 2002

  • Alauddin, Mian M.; Conti, Peter S.; Fissekis, John D.
  • Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 45, Issue 7
  • https://doi.org/10.1002/jlcr.549

Nucleoside and nucleobase transport systems of mammalian cells
journal, October 1996


KEGG: Kyoto Encyclopedia of Genes and Genomes
journal, January 2000


Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome
journal, May 2001


NetAffx: Affymetrix probesets and annotations
journal, January 2003


Synthesis and tumour-localizing properties of [18F]-5-fluorocytosine-arabinoside and [18F]-5-fluorocyclocytidine
journal, July 1986


Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?
journal, June 2007


The equilibrative nucleoside transporter family, SLC29
journal, February 2004


Fuel feeds function: energy metabolism and the T-cell response
journal, October 2005


Imaging DNA synthesis with [18F]FMAU and positron emission tomography in patients with cancer
journal, December 2004


Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection
journal, January 2001


Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis
journal, January 2007


Structure and function of cellular deoxyribonucleoside kinases
journal, August 2002


Differential Kinetics of Antigen-Specific CD4 + and CD8 + T Cell Responses in the Regression of Retrovirus-Induced Sarcomas
journal, September 2002


Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells
journal, August 2003


Fluorinated nucleosides
journal, July 2000


Positron emission tomography provides molecular imaging of biological processes
journal, August 2000


Quantitative imaging of the T cell antitumor response by positron-emission tomography
journal, January 2003


Biodistribution and PET imaging of [18F]-fluoroadenosine derivatives
journal, April 2007


Regulation of T Lymphocyte Metabolism
journal, April 2004


The concentrative nucleoside transporter family, SLC28
journal, February 2004


Imaging proliferation in vivo with [F-18]FLT and positron emission tomography
journal, November 1998


Positron Emission Tomography Scanning: Current and Future Applications
journal, February 2002


High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner
journal, April 1998


Interaction of mutant lpr gene with background strain influences renal disease
journal, November 1985


Fluorodeoxyglucose Uptake in the Aortic Wall at PET/CT: Possible Finding for Active Atherosclerosis
journal, December 2003