Combining Transmission Geometry Laser Ablation and a Non Contact Continuous Flow Surface Sampling Probe/Electrospray Emitter for Mass Spectrometry-Based Chemical Imaging
- ORNL
This paper describes the coupling of ambient pressure transmission geometry laser ablation with a liquid phase sample collection into a continuous flow surface sampling probe/electrospray emitter for mass spectrometry based chemical imaging. The flow probe/emitter device was placed in close proximity to the surface to collect the sample plume produced by laser ablation. The sample collected was immediately aspirated into the probe and on to the electrospray emitter, ionized and detected with the mass spectrometer. Freehand drawn ink lines and letters and an inked fingerprint on microscope slides were analyzed. The circular laser ablation area was about 210 m in diameter and under the conditions used in these experiments the spatial resolution, as determined by the size of the surface features distinguished in the chemical images, was about 100 m.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC)
- DOE Contract Number:
- DE-AC05-00OR22725
- OSTI ID:
- 1032812
- Journal Information:
- Rapid Communications in Mass Spectrometry, Vol. 25, Issue 24; ISSN 0951-4198
- Country of Publication:
- United States
- Language:
- English
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