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Title: Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.

Abstract

This is the final report for the President Harry S. Truman Fellowship in National Security Science and Engineering (LDRD project 130813) awarded to Dr. Bryan Kaehr from 2008-2011. Biological chemistries, cells, and integrated systems (e.g., organisms, ecologies, etc.) offer important lessons for the design of synthetic strategies and materials. The desire to both understand and ultimately improve upon biological processes has been a driving force for considerable scientific efforts worldwide. However, to impart the useful properties of biological systems into modern devices and materials requires new ideas and technologies. The research herein addresses aspects of these issues through the development of (1) a rapid-prototyping methodology to build 3D bio-interfaces and catalytic architectures, (2) a quantitative method to measure cell/material mechanical interactions in situ and at the microscale, and (3) a breakthrough approach to generate functional biocomposites from bacteria and cultured cells.

Authors:
Publication Date:
Research Org.:
Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1029826
Report Number(s):
SAND2011-6892
TRN: US201201%%235
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Technical Report
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; BACTERIA; DESIGN; FUNCTIONALS; BIOLOGY; CHEMISTRY

Citation Formats

Kaehr, Bryan James. Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.. United States: N. p., 2011. Web. doi:10.2172/1029826.
Kaehr, Bryan James. Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.. United States. https://doi.org/10.2172/1029826
Kaehr, Bryan James. 2011. "Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.". United States. https://doi.org/10.2172/1029826. https://www.osti.gov/servlets/purl/1029826.
@article{osti_1029826,
title = {Development and characterization of 3D, nano-confined multicellular constructs for advanced biohybrid devices.},
author = {Kaehr, Bryan James},
abstractNote = {This is the final report for the President Harry S. Truman Fellowship in National Security Science and Engineering (LDRD project 130813) awarded to Dr. Bryan Kaehr from 2008-2011. Biological chemistries, cells, and integrated systems (e.g., organisms, ecologies, etc.) offer important lessons for the design of synthetic strategies and materials. The desire to both understand and ultimately improve upon biological processes has been a driving force for considerable scientific efforts worldwide. However, to impart the useful properties of biological systems into modern devices and materials requires new ideas and technologies. The research herein addresses aspects of these issues through the development of (1) a rapid-prototyping methodology to build 3D bio-interfaces and catalytic architectures, (2) a quantitative method to measure cell/material mechanical interactions in situ and at the microscale, and (3) a breakthrough approach to generate functional biocomposites from bacteria and cultured cells.},
doi = {10.2172/1029826},
url = {https://www.osti.gov/biblio/1029826}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 2011},
month = {Thu Sep 01 00:00:00 EDT 2011}
}