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Id-1 and Id-2 genes and products as markers of epithelial cancer

Patent ·
OSTI ID:1029286
 [1];  [2]
  1. El Cerrito, CA
  2. Berkeley, CA
+ Show Author Affiliations
A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is a prognostic indicator that breast cancer cells are invasive and metastatic, whereas Id-2 gene is a prognostic indicator that breast cancer cells are localized and noninvasive in the breast tissue.
Research Organization:
University of California
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098; AC02-05CH11231
Assignee:
OAK
Patent Number(s):
8,030,012
Application Number:
11/390,682
OSTI ID:
1029286
Country of Publication:
United States
Language:
English

References (17)

Interphase cytogenetics and comparative genomic hybridization of human epithelial cancers and precursor lesions journal October 1997
The Id proteins: targets for inhibiting tumor cells and their blood supply journal October 2001
Id1 expression is associated with histological grade and invasive behavior in endometrial carcinoma journal April 2001
Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer journal March 2003
Gene expression profiling predicts clinical outcome of prostate cancer journal March 2004
Systemic Gene Delivery Expands the Repertoire of Effective Antiangiogenic Agents journal May 1999
Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer journal September 2007
Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma journal September 2005
ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value journal January 2003
Overexpression of the Helix–Loop–Helix protein Id2 blocks T cell development at multiple stages journal June 1999
Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat journal June 2001
Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis journal September 1999
Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression journal March 2004
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis journal October 2003
Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. journal June 1995
Over Expression of ID-1 in Prostate Cancer journal June 2002
Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma journal November 2007

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