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Synthetic peptides that cause F-actin bundling and block actin depolymerization

Patent ·
OSTI ID:1028779
 [1];  [2];  [3]
  1. Raleigh, NC
  2. Savoy, IL
  3. Berkeley, CA
+ Show Author Affiliations
Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.
Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098;
Other Award/Contract Number:
AI01-91ER20031
Assignee:
The Regents of the University of California (Oakland, CA); North Carolina State University (Raleigh, NC); The Regents of the University of California (Oakland, CA)
Patent Number(s):
8,039,438
Application Number:
10/576,757
OSTI ID:
1028779
Country of Publication:
United States
Language:
English

References (6)

The actin genes of drosophila: Protein coding regions are highly conserved but intron positions are not journal April 1981
A common theme in the amino acid sequences of actin and many actin-binding proteins? journal April 1989
Identification of sucrose synthase as an actin-binding protein journal July 1998
A peptide carrier for the delivery of biologically active proteins into mammalian cells journal December 2001
Complete Nucleotide Sequence of the Maize (Zea mays L.) Sucrose Synthase 2 cDNA journal January 1994
Biochemical, Physiological, and Molecular Characterization of Sucrose Synthase from Daucus carota journal May 1995

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES