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Title: Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism

Abstract

A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency .omega..sub.1, a second light source for providing a second train of pulses at a second center optical frequency .omega..sub.2, a modulator system, an optical detector, and a processor. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of the first train of pulses from the common focal volume by blocking the second train of pulses being modulated. The processor is for detecting, a modulation at the modulation frequency f, of the integrated intensity of the optical frequency components of the first train of pulses to provide a pixel of an image for the microscopy imaging system.

Inventors:
 [1];  [2];  [3]
  1. Lexington, MA
  2. Boston, MA
  3. Cambridge, MA
Publication Date:
Research Org.:
President & Fellows of Harvard College (Cambridge, MA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1027112
Patent Number(s):
8,027,032
Application Number:
12/196,746
Assignee:
President & Fellows of Harvard College (Cambridge, MA)
DOE Contract Number:  
FG02-07ER15875
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Xie, Xiaoliang Sunney, Freudiger, Christian, and Min, Wei. Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism. United States: N. p., 2011. Web.
Xie, Xiaoliang Sunney, Freudiger, Christian, & Min, Wei. Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism. United States.
Xie, Xiaoliang Sunney, Freudiger, Christian, and Min, Wei. Tue . "Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism". United States. https://www.osti.gov/servlets/purl/1027112.
@article{osti_1027112,
title = {Microscopy imaging system and method employing stimulated raman spectroscopy as a contrast mechanism},
author = {Xie, Xiaoliang Sunney and Freudiger, Christian and Min, Wei},
abstractNote = {A microscopy imaging system includes a first light source for providing a first train of pulses at a first center optical frequency .omega..sub.1, a second light source for providing a second train of pulses at a second center optical frequency .omega..sub.2, a modulator system, an optical detector, and a processor. The modulator system is for modulating a beam property of the second train of pulses at a modulation frequency f of at least 100 kHz. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of the first train of pulses from the common focal volume by blocking the second train of pulses being modulated. The processor is for detecting, a modulation at the modulation frequency f, of the integrated intensity of the optical frequency components of the first train of pulses to provide a pixel of an image for the microscopy imaging system.},
doi = {},
url = {https://www.osti.gov/biblio/1027112}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {9}
}

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Works referenced in this record:

The Stimulated Raman Effect
journal, November 1967


Coherent Raman gain spectroscopy using CW laser sources
journal, March 1978


FM spectroscopy detection of stimulated Raman gain
journal, January 1983


Ultrahigh sensitivity stimulated Raman gain spectroscopy
journal, January 1980


Frequency‐modulated shot noise limited stimulated Raman gain spectroscopy
journal, February 1980


Surface vibrational spectroscopy using stimulated Raman scattering
journal, December 1979


Femtosecond stimulated Raman microscopy
journal, April 2007


Inverse Raman spectroscopy in dye solutions with synchronized cw picosecond lasers
journal, October 1984


High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy
journal, January 2006


Sensitivity limitations for CW stimulated Raman spectroscopy
journal, September 1977