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Title: Unnatural reactive amino acid genetic code additions

Abstract

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Inventors:
 [1];  [2];  [3];  [4];  [1]
  1. La Jolla, CA
  2. Bethesda, MD
  3. Cambridge, GB
  4. San Francisco, CA
Publication Date:
Research Org.:
The Scripps Research Institute (La Jolla, CA)
Sponsoring Org.:
USDOE
OSTI Identifier:
1026521
Patent Number(s):
7,993,872
Application Number:
US patent applicaiton 10/561,121
Assignee:
The Scripps Research Institute (La Jolla, CA) OSTI
DOE Contract Number:  
FG03-00ER45812
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Deiters, Alexander, Cropp, T Ashton, Chin, Jason W, Anderson, J Christopher, and Schultz, Peter G. Unnatural reactive amino acid genetic code additions. United States: N. p., 2011. Web.
Deiters, Alexander, Cropp, T Ashton, Chin, Jason W, Anderson, J Christopher, & Schultz, Peter G. Unnatural reactive amino acid genetic code additions. United States.
Deiters, Alexander, Cropp, T Ashton, Chin, Jason W, Anderson, J Christopher, and Schultz, Peter G. Tue . "Unnatural reactive amino acid genetic code additions". United States. https://www.osti.gov/servlets/purl/1026521.
@article{osti_1026521,
title = {Unnatural reactive amino acid genetic code additions},
author = {Deiters, Alexander and Cropp, T Ashton and Chin, Jason W and Anderson, J Christopher and Schultz, Peter G},
abstractNote = {This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsyn-thetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 09 00:00:00 EDT 2011},
month = {Tue Aug 09 00:00:00 EDT 2011}
}

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