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Title: Structure of Plasmodium falciparum ADP-ribosylation factor 1

Abstract

Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 {angstrom} resolution and is compared with the structures of mammalian ARF1s.

Authors:
; ; ; ;  [1];  [2]
  1. (UAB)
  2. (
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
DOE - BASIC ENERGY SCIENCES
OSTI Identifier:
1025631
Resource Type:
Journal Article
Journal Name:
Acta Crystallogr. F
Additional Journal Information:
Journal Volume: 66; Journal Issue: (11) ; 11, 2010; Journal ID: ISSN 1744-3091
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; CRYSTAL STRUCTURE; MALARIA; PATHOGENESIS; PLASMODIUM; PROTEINS; RESOLUTION

Citation Formats

Cook, William J., Smith, Craig D., Senkovich, Olga, Holder, Anthony A., Chattopadhyay, Debasish, and NIMR). Structure of Plasmodium falciparum ADP-ribosylation factor 1. United States: N. p., 2011. Web. doi:10.1107/S1744309110036997.
Cook, William J., Smith, Craig D., Senkovich, Olga, Holder, Anthony A., Chattopadhyay, Debasish, & NIMR). Structure of Plasmodium falciparum ADP-ribosylation factor 1. United States. doi:10.1107/S1744309110036997.
Cook, William J., Smith, Craig D., Senkovich, Olga, Holder, Anthony A., Chattopadhyay, Debasish, and NIMR). Mon . "Structure of Plasmodium falciparum ADP-ribosylation factor 1". United States. doi:10.1107/S1744309110036997.
@article{osti_1025631,
title = {Structure of Plasmodium falciparum ADP-ribosylation factor 1},
author = {Cook, William J. and Smith, Craig D. and Senkovich, Olga and Holder, Anthony A. and Chattopadhyay, Debasish and NIMR)},
abstractNote = {Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes. The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 {angstrom} resolution and is compared with the structures of mammalian ARF1s.},
doi = {10.1107/S1744309110036997},
journal = {Acta Crystallogr. F},
issn = {1744-3091},
number = (11) ; 11, 2010,
volume = 66,
place = {United States},
year = {2011},
month = {9}
}