A method for preparing sodium acrylate-d3, a useful and stable precursor for deuterated acrylic monomers

Journal Article · Sat Jan 01 00:00:00 EST 2011 · Journal of Labelled Compounds and Radiopharmaceuticals

DOI:https://doi.org/10.1002/jlcr.1915· OSTI ID:1023314

Yang, Jun ^[1]; Hong, Kunlun ^[1]; Bonnesen, Peter V ^[1]

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1. ORNL

A convenient and economical method for converting propiolic acid to sodium acrylate-d3 is described. Successive D/H exchange of the alkyne proton of sodium propiolate (prepared from propiolic acid) using D2O affords sodium propiolate-d having up to 99 atom% D. Sodium propiolate-d can be partially reduced to sodium acrylate-d3 with 90% conversion and 89% yield, using D2 and the Lindlar catalyst with control of reaction parameters to maximize conversion while minimizing over reduction.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: DE-AC05-00OR22725
• OSTI ID: 1023314
• Journal Information: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 54, Issue 12; ISSN 0362-4803
• Country of Publication: United States
• Language: English

Related Subjects

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
ALKYNES
CATALYSTS
MONOMERS
PRECURSOR
PROTONS
SODIUM
sodium acrylate-d3
deuterated acrylic monomer