Single nanoparticle tracking spectroscopic microscope

Yang, Haw; Cang, Hu; Xu, Cangshan; Wong, Chung M

Title: Single nanoparticle tracking spectroscopic microscope

Patent · Tue Jul 19 00:00:00 EDT 2011

OSTI ID:1019417

Yang, Haw ^[1]; Cang, Hu ^[2]; Xu, Cangshan ^[2]; Wong, Chung M ^[3]

Moraga, CA
Berkeley, CA
San Gabriel, CA

A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 7,982,194

Application Number:: US Patent Application 12/144,514

OSTI ID:: 1019417

Country of Publication:: United States

Language:: English

References (7)

Control of Nanoparticles with Arbitrary Two-Dimensional Force Fields Cohen, Adam E. Physical Review Letters, Vol. 94, Issue 11 https://doi.org/10.1103/PhysRevLett.94.118102	journal	March 2005
How to Track Bacteria Berg, Howard C. Review of Scientific Instruments, Vol. 42, Issue 6 https://doi.org/10.1063/1.1685246	journal	June 1971
Progress in single-molecule tracking spectroscopy Cang, Hu; Shan Xu, C.; Yang, Haw Chemical Physics Letters, Vol. 457, Issue 4-6 https://doi.org/10.1016/j.cplett.2008.03.098	journal	May 2008
Three dimensional single-particle tracking with nanometer resolution Peters, Inge M.; de Grooth, Bart G.; Schins, Juleon M. Review of Scientific Instruments, Vol. 69, Issue 7 https://doi.org/10.1063/1.1149012	journal	July 1998
High-throughput scanning confocal microscope for single molecule analysis Sabanayagam, Chandran R.; Eid, John S.; Meller, Amit Applied Physics Letters, Vol. 84, Issue 7 https://doi.org/10.1063/1.1646725	journal	February 2004
Tracking of fluorescent molecules diffusing within membranes Enderlein, J. Applied Physics B, Vol. 71, Issue 5 https://doi.org/10.1007/s003400000409	journal	November 2000
Confocal three dimensional tracking of a single nanoparticle with concurrent spectroscopic readouts Cang, Hu; Wong, Chung M.; Xu, C. Shan Applied Physics Letters, Vol. 88, Issue 22 https://doi.org/10.1063/1.2204652	journal	May 2006

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