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Title: Peptides whose uptake by cells is controllable

Patent ·
OSTI ID:1019404
 [1];  [2];  [1];  [2]
  1. San Diego, CA
  2. La Jolla, CA
+ Show Author Affiliations

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Research Organization:
University of California (Oakland, CA)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG03-01ER63276
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,985,401
Application Number:
US Patent Application 11/133,804
OSTI ID:
1019404
Country of Publication:
United States
Language:
English

References (5)

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring journal October 1999
Tumor imaging by means of proteolytic activation of cell-penetrating peptides journal December 2004
Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney: VI. Specificity: Amino acids, their N-methyl-, N-acetyl- and N-benzoylderivatives; glutathione- and cysteine conjugates, di- and oligopeptides journal December 1989
Macrocyclic Chelators with Paramagnetic Cations Are Internalized into Mammalian Cells via a HIV-Tat Derived Membrane Translocation Peptide journal May 2000
Visualizing the mechanical activation of Src journal April 2005

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES