Portable sample preparation and analysis system for micron and sub-micron particle characterization using light scattering and absorption spectroscopy

Patent · 26 July 2011

OSTI ID:1019396

Stark, Peter C ^[1]; Zurek, Eduardo ^[2]; Wheat, Jeffrey V ^[3]; Dunbar, John M ^[4]; Olivares, Jose A ^[1]; Garcia-Rubio, Luis H ^[5]; Ward, Michael D ^[1]

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1. Los Alamos, NM
2. Barranquilla, CO
3. Fort Walton Beach, FL
4. Santa Fe, NM
5. Temple Terrace, FL

There is provided a method and device for remote sampling, preparation and optical interrogation of a sample using light scattering and light absorption methods. The portable device is a filtration-based device that removes interfering background particle material from the sample matrix by segregating or filtering the chosen analyte from the sample solution or matrix while allowing the interfering background particles to be pumped out of the device. The segregated analyte is then suspended in a diluent for analysis. The device is capable of calculating an initial concentration of the analyte, as well as diluting the analyte such that reliable optical measurements can be made. Suitable analytes include cells, microorganisms, bioparticles, pathogens and diseases. Sample matrixes include biological fluids such as blood and urine, as well as environmental samples including waste water.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC52-06NA25396
• Assignee: Los Alamos National Security, LLC (Los Alamos, NM)
• Patent Number(s): 7,986,399
• Application Number: US Patent Application 11/877,136
• OSTI ID: 1019396
• Country of Publication: United States
• Language: English

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