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Title: System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures

Patent ·
OSTI ID:1019120
 [1];  [2];  [1];  [2];  [3]
  1. Richland, WA
  2. West Richland, WA
  3. Benton City, WA
+ Show Author Affiliations

An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RLO1830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
7,956,328
Application Number:
US Patent Application 12/511,833
OSTI ID:
1019120
Country of Publication:
United States
Language:
English

References (5)

A technique for monitoring mammalian cell growth and inhibition in situ via Fourier transform infrared spectroscopy journal November 1988
In situ monitoring of the biofilm formation of Pseudomonas putida on hematite using flow-cell ATR-FTIR spectroscopy to investigate the formation of inner-sphere bonds between the bacteria and the mineral journal February 2008
Recent advancements in surface plasmon resonance immunosensors for detection of small molecules of biomedical, food and environmental interest journal January 2007
In situ observation of a cell adhesion and metabolism using surface infrared spectroscopy journal November 2007
Quantitative and simultaneous detection of four foodborne bacterial pathogens with a multi-channel SPR sensor journal December 2006

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60 APPLIED LIFE SCIENCES