Optical diagnostics based on elastic scattering: An update of clinical demonstrations with the Optical Biopsy System

Conference · Sat Oct 01 00:00:00 EDT 1994

OSTI ID:10187609

Bigio, I J; Boyer, J; Johnson, T M; Lacey, J; Mourant, J R ^[1]; Conn, R ^[2]; Bohorfoush, A ^[3]

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1. Los Alamos National Lab., NM (United States)
2. Lovelace Medical Center, Albuquerque, NM (United States)
3. Wisconsin Medical School, Milwaukee, WI (United States)

The Los Alamos National Laboratory has continued the development of the Optical Biopsy System (OBS) for noninvasive, real-time in situ diagnosis of tissue pathologies. Our clinical studies have expanded since the last Biomedical Optics Europe conference (Budapest, September 1993), and we report here on the latest results of clinical tests in gastrointestinal tract. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the tissue. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength-dependence of elastic scattering. The OBS employs a small fiberoptic probe that is amenable to use with any endoscope or catheter, or to direct surface examination. The probe is designed to be used in optical contact with the tissue under examination and has separate illuminating and collecting fibers. Thus, the light that is collected and transmitted to the analyzing spectrometer must first scatter through a small volume of the tissue before entering the collection fiber(s). Consequently, the system is also sensitive to the optical absorption spectrum of the tissue, over an effective operating range of <300 to 950 nm, and such absorption adds valuable complexity to the scattering spectral signature.

• Research Organization: Los Alamos National Lab., NM (United States)
• Sponsoring Organization: National Science Foundation, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 10187609
• Report Number(s): LA-UR-94-3255; CONF-9409220-1; ON: DE95000942; TRN: 94:009259
• Resource Relation: Conference: SPIE biomedical optics,Lille (France),5-9 Sep 1994; Other Information: PBD: [1994]
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
47 OTHER INSTRUMENTATION
ELASTIC SCATTERING
FEASIBILITY STUDIES
PATHOLOGICAL CHANGES
DIAGNOSTIC TECHNIQUES
BIOPSY
DATA ACQUISITION
GASTROINTESTINAL TRACT
MORPHOLOGY
FIBER OPTICS
550600
550900
440600
MEDICINE
PATHOLOGY
OPTICAL INSTRUMENTATION