Nuclear, chemical, and mechanistic considerations in the use of {sup 117m}Sn(4+)-DTPA relative to {sup 186}Re-HEDP and other agents for bone pain therapy

Conference · Sat Oct 01 00:00:00 EDT 1994

OSTI ID:10186592

Srivastava, S C; Meinken, G E; Mausner, L F; Atkins, H L ^[1]; Cutler, C; Deutsch, E ^[2]

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1. Brookhaven National Lab., Upton, NY (United States)
2. Cincinnati Univ., OH (United States). Dept. of Radiology

This paper summarizes the results of our mechanistic studies on {sup 117m}Sn(4+){minus} DTPA to determine (i) the effect of oxidation state and specific activity of {sup 117m}Sn, (ii) effect of the addition of calcium, (iii) the nature of chemical species of tin in blood and urine, and (iv) kinetics of uptake and washout of radioactivity from bone relative to technetium, rhenium, and samarium bone agents.

• Research Organization: Brookhaven National Lab., Upton, NY (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 10186592
• Report Number(s): BNL-60431; CONF-9409117-3; ON: DE95000814
• Resource Relation: Conference: 4. international symposium on technetium in chemistry and nuclear chemistry,Bressanone (Italy),12-14 Sep 1994; Other Information: PBD: [1994]
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DTPA
TISSUE DISTRIBUTION
TIN COMPLEXES
ORGANOMETALLIC COMPOUNDS
TIN 117
RADIOTHERAPY
MICE
COMPARATIVE EVALUATIONS
BONE TISSUES
RADIOPHARMACEUTICALS
RATS
550604
560162
UNSEALED RADIONUCLIDES IN THERAPY
ANIMALS, PLANTS, MICROORGANISMS, AND CELLS