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Title: Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the Los Alamos Optical Biopsy System

Abstract

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be strongly wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength dependence of elastic scattering. The data acquisition and storage/display time with the OBS instrument is {approximately}1 second. Thus, in addition to the reduced invasiveness of this technique compared with currentmore » state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g. as in skin cancer or cervical cancer). It has been tested in vitro on animal and human tissue samples, and clinical testing in vivo is currently in progress.« less

Authors:
; ; ;  [1]; ;  [2];  [3]
  1. Los Alamos National Lab., NM (United States)
  2. Texas Univ. Health Science Center, San Antonio, TX (United States). Dept. of Ophthalmology
  3. Lovelace Medical Center, Albuquerque, NM (United States). Dept. of Urology
Publication Date:
Research Org.:
Los Alamos National Lab., NM (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
10176682
Report Number(s):
LA-UR-93-2764
ON: DE93018289
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: [1993]
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; BIOASSAY; INFRARED SPECTROMETERS; DIAGNOSTIC USES; FIBER OPTICS; FLUORESCENCE SPECTROSCOPY; MAN; DOGS; BLADDER; 550600; MEDICINE

Citation Formats

Bigio, I.J., Loree, T.R., Mourant, J., Shimada, T., Story-Held, K., Glickman, R.D., and Conn, R.. Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the Los Alamos Optical Biopsy System. United States: N. p., 1993. Web. doi:10.2172/10176682.
Bigio, I.J., Loree, T.R., Mourant, J., Shimada, T., Story-Held, K., Glickman, R.D., & Conn, R.. Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the Los Alamos Optical Biopsy System. United States. doi:10.2172/10176682.
Bigio, I.J., Loree, T.R., Mourant, J., Shimada, T., Story-Held, K., Glickman, R.D., and Conn, R.. Sun . "Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the Los Alamos Optical Biopsy System". United States. doi:10.2172/10176682. https://www.osti.gov/servlets/purl/10176682.
@article{osti_10176682,
title = {Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the Los Alamos Optical Biopsy System},
author = {Bigio, I.J. and Loree, T.R. and Mourant, J. and Shimada, T. and Story-Held, K. and Glickman, R.D. and Conn, R.},
abstractNote = {A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be strongly wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength dependence of elastic scattering. The data acquisition and storage/display time with the OBS instrument is {approximately}1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g. as in skin cancer or cervical cancer). It has been tested in vitro on animal and human tissue samples, and clinical testing in vivo is currently in progress.},
doi = {10.2172/10176682},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {8}
}