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Title: Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate

Abstract

Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in mixed-sugars medium comprising xylose, and, in particular, in the presence of acetate.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [6];  [2];  [7]
  1. Kennett Square, PA
  2. Lakewood, CO
  3. Centennial, CO
  4. Newark, DE
  5. Havertown, PA
  6. West Chester, PA
  7. New Hope, PA
Publication Date:
Research Org.:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1016555
Patent Number(s):
7,897,396
Application Number:
US Patent Application 12/261,160
Assignee:
E.I. du Pont de Nemours and Company (Wilmington, DE); Alliance for Sustainable Energy LLC ( NREL
DOE Contract Number:  
AC36-08GO28308
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Caimi, Perry G, Chou, Yat-Chen, Franden, Mary Ann, Knoke, Kyle, Tao, Luan, Viitanen, Paul V, Zhang, Min, and Zhang, Yuying. Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate. United States: N. p., 2011. Web.
Caimi, Perry G, Chou, Yat-Chen, Franden, Mary Ann, Knoke, Kyle, Tao, Luan, Viitanen, Paul V, Zhang, Min, & Zhang, Yuying. Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate. United States.
Caimi, Perry G, Chou, Yat-Chen, Franden, Mary Ann, Knoke, Kyle, Tao, Luan, Viitanen, Paul V, Zhang, Min, and Zhang, Yuying. Tue . "Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate". United States. https://www.osti.gov/servlets/purl/1016555.
@article{osti_1016555,
title = {Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate},
author = {Caimi, Perry G and Chou, Yat-Chen and Franden, Mary Ann and Knoke, Kyle and Tao, Luan and Viitanen, Paul V and Zhang, Min and Zhang, Yuying},
abstractNote = {Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when cultured in mixed-sugars medium comprising xylose, and, in particular, in the presence of acetate.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2011},
month = {3}
}

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