Salmonella-secreted Virulence Factors
In this short review we discuss secreted virulence factors of Salmonella, which directly affect Salmonella interaction with its host. Salmonella secretes protein to subvert host defenses but also, as discussed, to reduce virulence thereby permitting the bacteria to persist longer and more successfully disperse. The type III secretion system (TTSS) is the best known and well studied of the mechanisms that enable secretion from the bacterial cytoplasm to the host cell cytoplasm. Other secretion systems include outer membrane vesicles, which are present in all Gram-negative bacteria examined to date, two-partner secretion, and type VI secretion will also be addressed. Excellent reviews of Salmonella secreted effectors have focused on themes such as actin rearrangements, vesicular trafficking, ubiquitination, and the activities of the virulence factors themselves. This short review is based on S. Typhimurium infection of mice because it is a model of typhoid like disease in humans. We have organized effectors in terms of events that happen during the infection cycle and how secreted effectors may be involved.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1015521
- Report Number(s):
- PNNL-SA-71401; 400412000; TRN: US201111%%641
- Resource Relation:
- Related Information: Salmonella: From Genome to Function, 187-223
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ACTIN
BACTERIA
CYTOPLASM
DISEASES
MEMBRANES
MICE
PROTEINS
SALMONELLA
SECRETION
TYPHOID
VIRULENCE
ENTERICA SEROVAR TYPHIMURIUM
T-CELL RESPONSES
LYSOSOMAL
MEMBRANE-GLYCOPROTEINS
PHOSPHOTHREONINE LYASE ACTIVITY
LATE ENDOCYTIC COMPARTMENTS
NUCLEOTIDE EXCHANGE FACTOR
ACTIN-BINDING PROTEINS
B-ALPHA UBIQUITINATION
III EFFECTOR FAMILY
NF-KAPPA-B