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Title: Method of increasing radiation sensitivity by inhibition of beta one integrin

Abstract

A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.

Inventors:
 [1];  [2]
  1. San Francisco, CA
  2. Berkeley, CA
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1015162
Patent Number(s):
7,618,627
Application Number:
11/628,476
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Park, Catherine, and Bissell, Mina J. Method of increasing radiation sensitivity by inhibition of beta one integrin. United States: N. p., 2009. Web.
Park, Catherine, & Bissell, Mina J. Method of increasing radiation sensitivity by inhibition of beta one integrin. United States.
Park, Catherine, and Bissell, Mina J. Tue . "Method of increasing radiation sensitivity by inhibition of beta one integrin". United States. https://www.osti.gov/servlets/purl/1015162.
@article{osti_1015162,
title = {Method of increasing radiation sensitivity by inhibition of beta one integrin},
author = {Park, Catherine and Bissell, Mina J},
abstractNote = {A method for increasing or monitoring apoptosis in tumor cells by the co-administration of ionizing radiation and an anti-integrin antibody. Increasing apoptosis reduces tumor growth in vivo and in a cell culture model. The antibody is directed against the beta-1 integrin subunit and is inhibitory of beta-1 integrin signaling. Other molecules having an inhibitory effect on beta-1 integrin, either in signaling or in binding to its cognate extracellular receptors may also be used. The present method is particularly of interest in treatment of tumor cells associated with breast cancer, wherein radiation is currently used alone. The present method further contemplates a monoclonal antibody suitable for human administration that may further comprise a radioisotope attached thereto.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2009},
month = {11}
}

Patent:

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