High-resolution retinal imaging using adaptive optics and Fourier-domain optical coherence tomography

Patent · 07 September 2010

OSTI ID:1014691

Olivier, Scot S ^[1]; Werner, John S ^[2]; Zawadzki, Robert J ^[3]; Laut, Sophie P ^[4]; Jones, Steven M ^[1]

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1. Livermore, CA
2. Davis, CA
3. Sacramento, CA
4. Pasedena, CA

This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4.times.4.times.6 .mu.m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

• Research Organization: Lawrence Livermore National Security, LLC (Livermore, CA); University of California (Oakland, CA)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG-48
• Assignee: Lawrence Livermore National Security, LLC (Livermore, CA); University of California (Oakland, CA)
• Patent Number(s): 7,791,734
• Application Number: US Patent Application 11/417,074
• OSTI ID: 1014691
• Country of Publication: United States
• Language: English