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Title: Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof

Abstract

The present invention provides methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristic. The present invention demonstrates that many tumor cells lack normal cell surface .alpha.-dystroglycan and thereby lack dystroglycan function. Dystroglycan can be lost from the cell surface by proteolytic shedding of a fragment of .alpha.-dystroglycan into the surrounding medium. Upon restoration of dystroglycan function and over-expression of the dystroglycan gene, the once tumorigenic cells revert to non-tumorigenic cells which polarize and arrest cell growth in the presence of basement membrane proteins, demonstrating that dystroglycan functions as a tumor marker and suppressor.

Inventors:
 [1];  [2]
  1. (Berkeley, CA)
  2. (Albany, CA)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1014177
Patent Number(s):
7,666,850
Application Number:
US Patent Application 11/150,406
Assignee:
The Regents of the University of California (Oakland, CA) LBNL
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Bissell, Mina J., and Muschler, John L. Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof. United States: N. p., 2010. Web.
Bissell, Mina J., & Muschler, John L. Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof. United States.
Bissell, Mina J., and Muschler, John L. Tue . "Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof". United States. https://www.osti.gov/servlets/purl/1014177.
@article{osti_1014177,
title = {Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof},
author = {Bissell, Mina J. and Muschler, John L.},
abstractNote = {The present invention provides methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristic. The present invention demonstrates that many tumor cells lack normal cell surface .alpha.-dystroglycan and thereby lack dystroglycan function. Dystroglycan can be lost from the cell surface by proteolytic shedding of a fragment of .alpha.-dystroglycan into the surrounding medium. Upon restoration of dystroglycan function and over-expression of the dystroglycan gene, the once tumorigenic cells revert to non-tumorigenic cells which polarize and arrest cell growth in the presence of basement membrane proteins, demonstrating that dystroglycan functions as a tumor marker and suppressor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {2}
}

Patent:

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