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Title: Problems in mechanistic theoretical models for cell transformation by ionizing radiation

Abstract

A mechanistic model based on yields of double strand breaks has been developed to determine the dose response curves for cell transformation frequencies. At its present stage the model is applicable to immortal cell lines and to various qualities (X-rays, Neon and Iron) of ionizing radiation. Presently, we have considered four types of processes which can lead to activation phenomena: (1) point mutation events on a regulatory segment of selected oncogenes, (2) inactivation of suppressor genes, through point mutation, (3) deletion of a suppressor gene by a single track, and (4) deletion of a suppressor gene by two tracks.

Authors:
;
Publication Date:
Research Org.:
Lawrence Berkeley Lab., CA (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
10135467
Report Number(s):
LBL-31398; CONF-9109107-5
ON: DE92010265
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: Workshop on biophysical modelling of radiation effects,Padua (Italy),2-5 Sep 1991; Other Information: PBD: Oct 1991
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; CARCINOGENESIS; MOLECULAR BIOLOGY; MUTAGENESIS; DNA; BIOLOGICAL RADIATION EFFECTS; IONIZING RADIATIONS; STRAND BREAKS; MUTATIONS; MATHEMATICAL MODELS; 560120; 990200; RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE; MATHEMATICS AND COMPUTERS

Citation Formats

Chatterjee, A, and Holley, W R. Problems in mechanistic theoretical models for cell transformation by ionizing radiation. United States: N. p., 1991. Web.
Chatterjee, A, & Holley, W R. Problems in mechanistic theoretical models for cell transformation by ionizing radiation. United States.
Chatterjee, A, and Holley, W R. Tue . "Problems in mechanistic theoretical models for cell transformation by ionizing radiation". United States. https://www.osti.gov/servlets/purl/10135467.
@article{osti_10135467,
title = {Problems in mechanistic theoretical models for cell transformation by ionizing radiation},
author = {Chatterjee, A and Holley, W R},
abstractNote = {A mechanistic model based on yields of double strand breaks has been developed to determine the dose response curves for cell transformation frequencies. At its present stage the model is applicable to immortal cell lines and to various qualities (X-rays, Neon and Iron) of ionizing radiation. Presently, we have considered four types of processes which can lead to activation phenomena: (1) point mutation events on a regulatory segment of selected oncogenes, (2) inactivation of suppressor genes, through point mutation, (3) deletion of a suppressor gene by a single track, and (4) deletion of a suppressor gene by two tracks.},
doi = {},
url = {https://www.osti.gov/biblio/10135467}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1991},
month = {10}
}

Conference:
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