Preliminary toxicology study of 3,6-diamino-1,2,4,5-tetrazine

Technical Report · Mon Mar 01 00:00:00 EST 1993

OSTI ID:10134627

London, J E

The calculated acute oral LD 30/50 (lethal dose for 50% of the animals occurring within 30 days after compound administration) value for 3,6-diamino-1,2,4,5-tetrazine (DATZ) was 863 mg/kg in rats. According to classical guidelines, DATZ would be considered slightly to moderately toxic for rats. The calculated acute oral LD {sub 30/50} value was 2,288 mg/kg in mice and would be considered slightly to moderately toxic for mice. Skin application studies using rabbits demonstrated DATZ to be a nonirritant. The eye study using rabbits disclosed DATZ to be a very mild irritant. The sensitization study using guinea pigs did not show DATZ to have potential sensitizing properties.

• Research Organization: Los Alamos National Lab., NM (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 10134627
• Report Number(s): LA-12346-MS; ON: DE93009117
• Resource Relation: Other Information: PBD: Mar 1993
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ORGANIC COMPOUNDS
TOXICITY
GUINEA PIGS
LETHAL DOSES
RATS
EYES
SKIN
MICE
RABBITS
BIOASSAY
560300
CHEMICALS METABOLISM AND TOXICOLOGY