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Title: Enzyme system comprising an enzyme bonded in a porous matrix

Abstract

A protein system is described in which a protein is bound within a matrix material that has pores that are sized to achieve excellent properties such as: activity, protein density, and stability. In a preferred embodiment, the pore sizes range from 50 to 400 .ANG.. One protein that has demonstrated surprisingly good results in this system is OPH. This protein is known to degrade organophosphorus compounds such as are found in chemical weapons and pesticides. Novel methods of forming the protein system and methods of making OPH are also described.

Inventors:
 [1];  [2]
  1. Richland, WA
  2. West Richland, WA
Publication Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1011441
Patent Number(s):
7,846,684
Application Number:
09/791,138
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Ackerman, Eric, and Liu, Jun. Enzyme system comprising an enzyme bonded in a porous matrix. United States: N. p., 2010. Web.
Ackerman, Eric, & Liu, Jun. Enzyme system comprising an enzyme bonded in a porous matrix. United States.
Ackerman, Eric, and Liu, Jun. Tue . "Enzyme system comprising an enzyme bonded in a porous matrix". United States. https://www.osti.gov/servlets/purl/1011441.
@article{osti_1011441,
title = {Enzyme system comprising an enzyme bonded in a porous matrix},
author = {Ackerman, Eric and Liu, Jun},
abstractNote = {A protein system is described in which a protein is bound within a matrix material that has pores that are sized to achieve excellent properties such as: activity, protein density, and stability. In a preferred embodiment, the pore sizes range from 50 to 400 .ANG.. One protein that has demonstrated surprisingly good results in this system is OPH. This protein is known to degrade organophosphorus compounds such as are found in chemical weapons and pesticides. Novel methods of forming the protein system and methods of making OPH are also described.},
doi = {},
url = {https://www.osti.gov/biblio/1011441}, journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}

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Works referenced in this record:

Mesoporous Silicate Sequestration and Release of Proteins
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Enhanced Enzymatic Reactions in a Microchannel Reactor
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Biosensor for direct determination of organophosphate nerve agents. 1. Potentiometric enzyme electrode
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Reusable immobilized enzyme/polyurethane sponge for removal and detoxification of localized organophosphate pesticide spills
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Entrapping Enzyme in a Functionalized Nanoporous Support
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Technology and Applications of Microengineered Reactors
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Functionalized Monolayers on Ordered Mesoporous Supports
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