Study of polymer molecules and conformations with a nanopore

Golovchenko, Jene A; Li, Jiali; Stein, Derek; Gershow, Marc H

Study of polymer molecules and conformations with a nanopore

Patent · 07 December 2010

OSTI ID:1011416

Golovchenko, Jene A ^[1]; Li, Jiali ^[2]; Stein, Derek ^[3]; Gershow, Marc H ^[4]

Lexington, MA
Fayetteville, AR
Delft, NL
Cambridge, MA

The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

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Research Organization:: Harvard College

Sponsoring Organization:: USDOE

Assignee:: CHO

Patent Number(s):: 7,846,738

Application Number:: 10/918,959

OSTI ID:: 1011416

Country of Publication:: United States

Language:: English

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