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Title: Study of polymer molecules and conformations with a nanopore

Abstract

The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.

Inventors:
 [1];  [2];  [3];  [4]
  1. (Lexington, MA)
  2. (Fayetteville, AR)
  3. (Delft, NL)
  4. (Cambridge, MA)
Publication Date:
Research Org.:
Harvard College
Sponsoring Org.:
USDOE
OSTI Identifier:
1011416
Patent Number(s):
7,846,738
Application Number:
10/918,959
Assignee:
CHO
DOE Contract Number:  
US patent application 10/918,959
Resource Type:
Patent
Country of Publication:
United States
Language:
English

Citation Formats

Golovchenko, Jene A., Li, Jiali, Stein, Derek, and Gershow, Marc H. Study of polymer molecules and conformations with a nanopore. United States: N. p., 2010. Web.
Golovchenko, Jene A., Li, Jiali, Stein, Derek, & Gershow, Marc H. Study of polymer molecules and conformations with a nanopore. United States.
Golovchenko, Jene A., Li, Jiali, Stein, Derek, and Gershow, Marc H. Tue . "Study of polymer molecules and conformations with a nanopore". United States. https://www.osti.gov/servlets/purl/1011416.
@article{osti_1011416,
title = {Study of polymer molecules and conformations with a nanopore},
author = {Golovchenko, Jene A. and Li, Jiali and Stein, Derek and Gershow, Marc H.},
abstractNote = {The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {12}
}

Patent:

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