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Title: Transgenic mice in developmental toxicology

Abstract

Advances in molecular biology and embryology are being utilized for the generation of transgenic mice, animals that contain specific additions, deletions, or modifications of genes or sequences in their DNA. Mouse embryonic stem cells and homologous recombination procedures have made it possible to target specific DNA structural alterations to highly localized region in the host chromosomes. The majority of the DNA structural rearrangements in transgenic mice can be passed through the germ line and used to establish new genetic traits in the carrier animals. Since the use of transgenic mice is having such an enormous impact on so many areas of mammalian biological research, including developmental toxicology, the objective of this review is to briefly describe the fundamental methodologies for generating transgenic mice and to describe one particular application that has direct relevance to the field of genetic toxicology.

Authors:
Publication Date:
Research Org.:
Oak Ridge National Lab., TN (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
10112134
Report Number(s):
CONF-9209272-1
ON: DE93003601
DOE Contract Number:  
AC05-84OR21400
Resource Type:
Conference
Resource Relation:
Conference: International conference on male-mediated developmental toxicity,Pittsburg, PA (United States),16-19 Sep 1992; Other Information: PBD: [1992]
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; MICE; GENETIC ENGINEERING; TERATOGENESIS; BIOLOGICAL MODELS; ONTOGENESIS; RECOMBINANT DNA; 560300; 560152; 550800; CHEMICALS METABOLISM AND TOXICOLOGY; ANIMALS; MORPHOLOGY

Citation Formats

Woychik, R.P.. Transgenic mice in developmental toxicology. United States: N. p., 1992. Web.
Woychik, R.P.. Transgenic mice in developmental toxicology. United States.
Woychik, R.P.. Thu . "Transgenic mice in developmental toxicology". United States.
@article{osti_10112134,
title = {Transgenic mice in developmental toxicology},
author = {Woychik, R.P.},
abstractNote = {Advances in molecular biology and embryology are being utilized for the generation of transgenic mice, animals that contain specific additions, deletions, or modifications of genes or sequences in their DNA. Mouse embryonic stem cells and homologous recombination procedures have made it possible to target specific DNA structural alterations to highly localized region in the host chromosomes. The majority of the DNA structural rearrangements in transgenic mice can be passed through the germ line and used to establish new genetic traits in the carrier animals. Since the use of transgenic mice is having such an enormous impact on so many areas of mammalian biological research, including developmental toxicology, the objective of this review is to briefly describe the fundamental methodologies for generating transgenic mice and to describe one particular application that has direct relevance to the field of genetic toxicology.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Dec 31 00:00:00 EST 1992},
month = {Thu Dec 31 00:00:00 EST 1992}
}

Conference:
Other availability
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