Structural basis for assembly and disassembly of the CRM1 nuclear export complex
CRM1 (or exportin 1, Xpo1) transports proteins out of the cell nucleus through the nuclear pore complex. In the cytoplasm, GTP hydrolysis and consequent dissociation of Ran from CRM1 releases low-affinity substrates, while additional factors facilitate release of high-affinity substrates. Here we provide a model for human CRM1 export complex assembly and disassembly through structural and biochemical analyses of CRM1 bound to the substrate snurportin 1 (SNUPN, also called snuportin 1).
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1005656
- Journal Information:
- Nat. Struct. Mol. Biol., Vol. 16, Issue (5) ; 05, 2009; ISSN 1545-9993
- Country of Publication:
- United States
- Language:
- ENGLISH
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