Synthesis and SAR of potent LXR agonists containing an indole pharmacophore
Journal Article
·
· Bioorg. Med. Chem. Lett.
A novel series of 1H-indol-1-yl tertiary amine LXR agonists has been designed. Compounds from this series were potent agonists with good rat pharmacokinetic parameters. In addition, the crystal structure of an LXR agonist bound to LXR{alpha} will be disclosed.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1005519
- Journal Information:
- Bioorg. Med. Chem. Lett., Vol. 19, Issue (4) ; 02, 2009; ISSN 0960-894X
- Country of Publication:
- United States
- Language:
- ENGLISH
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