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Title: Characterisation of amorphous and nanocrystalline molecular materials by total scattering

Abstract

The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticals carbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

Authors:
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  2. (
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
USDOE
OSTI Identifier:
1002651
Resource Type:
Journal Article
Resource Relation:
Journal Name: Cryst. Eng. Comm.; Journal Volume: 12; Journal Issue: 2010
Country of Publication:
United States
Language:
ENGLISH
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY; AMORPHOUS STATE; NANOSTRUCTURES; CRYSTAL STRUCTURE; X-RAY DIFFRACTION; DISTRIBUTION FUNCTIONS; DRUGS

Citation Formats

Billinge, Simon J.L., Dykhne, Timur, Juhás, Pavol, Boin, Emil, Taylor, Ryan, Florence, Alastair J., Shankland, Kenneth, Strathclyde), and Columbia). Characterisation of amorphous and nanocrystalline molecular materials by total scattering. United States: N. p., 2010. Web. doi:10.1039/b915453a.
Billinge, Simon J.L., Dykhne, Timur, Juhás, Pavol, Boin, Emil, Taylor, Ryan, Florence, Alastair J., Shankland, Kenneth, Strathclyde), & Columbia). Characterisation of amorphous and nanocrystalline molecular materials by total scattering. United States. doi:10.1039/b915453a.
Billinge, Simon J.L., Dykhne, Timur, Juhás, Pavol, Boin, Emil, Taylor, Ryan, Florence, Alastair J., Shankland, Kenneth, Strathclyde), and Columbia). Fri . "Characterisation of amorphous and nanocrystalline molecular materials by total scattering". United States. doi:10.1039/b915453a.
@article{osti_1002651,
title = {Characterisation of amorphous and nanocrystalline molecular materials by total scattering},
author = {Billinge, Simon J.L. and Dykhne, Timur and Juhás, Pavol and Boin, Emil and Taylor, Ryan and Florence, Alastair J. and Shankland, Kenneth and Strathclyde) and Columbia)},
abstractNote = {The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticals carbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.},
doi = {10.1039/b915453a},
journal = {Cryst. Eng. Comm.},
number = 2010,
volume = 12,
place = {United States},
year = {Fri Sep 17 00:00:00 EDT 2010},
month = {Fri Sep 17 00:00:00 EDT 2010}
}