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Title: Effects of estrogen and gender on cataractogenesis induced by high-LET radiation

Abstract

Planning for long-duration manned lunar and interplanetary missions requires an understanding of radiation-induced cataractogenesis. Previously, it was demonstrated that low-linear energy transfer (LET) irradiation with 10 Gy of {sup 60}Co {gamma} rays resulted in an increased incidence of cataracts in male rats compared to female rats. This gender difference was not due to differences in estrogen, since male rats treated with the major secreted estrogen 17-{beta}-estradiol (E2) showed an identical increase compared to untreated males. We now compare the incidence and rate of progression of cataracts induced by high-LET radiation in male and female Sprague-Dawley rats. Rats received a single dose of 1 Gy of 600 MeV {sup 56}Fe ions. Lens opacification was measured at 2-4 week intervals with a slit lamp. The incidence and rate of progression of radiation-induced cataracts was significantly increased in the animals in which estrogen was available from endogenous or exogenous sources. Male rats with E2 capsules implanted had significantly higher rates of progression compared to male rats with empty capsules implanted (P = 0.025) but not compared to the intact female rats. These results contrast with data obtained after low-LET irradiation and suggest the possibility that the different types of damage caused by high-more » and low-LET radiation may be influenced differentially by steroid sex hormones.« less

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Brookhaven National Laboratory (BNL) Nasa Space Radiation Laboratory
Sponsoring Org.:
National Aeronautics And Space Administration
OSTI Identifier:
1000434
Report Number(s):
BNL-91224-2010-JA
Journal ID: ISSN 0033-7587; ISSN 1938-5404; RAREAE; TRN: US1100113
DOE Contract Number:  
DE-AC02-98CH10886
Resource Type:
Journal Article
Journal Name:
Radiation Research
Additional Journal Information:
Journal Volume: 173; Journal Issue: 2; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; LET; CATARACTS; RATS; FEMALES; MALES; IRON 56; IRRADIATION; ESTROGENS; BIOLOGICAL RADIATION EFFECTS; SPACE FLIGHT; nasa space radiation laboratory

Citation Formats

Henderson, M.A., Rusek, A., Valluri, S., Garrett, J., Lopez, J., Caperell-Grant, A., Mendonca, M., Bigsby, R., and Dynlacht, J. Effects of estrogen and gender on cataractogenesis induced by high-LET radiation. United States: N. p., 2010. Web. doi:10.1667/RR1917.1.
Henderson, M.A., Rusek, A., Valluri, S., Garrett, J., Lopez, J., Caperell-Grant, A., Mendonca, M., Bigsby, R., & Dynlacht, J. Effects of estrogen and gender on cataractogenesis induced by high-LET radiation. United States. doi:10.1667/RR1917.1.
Henderson, M.A., Rusek, A., Valluri, S., Garrett, J., Lopez, J., Caperell-Grant, A., Mendonca, M., Bigsby, R., and Dynlacht, J. Mon . "Effects of estrogen and gender on cataractogenesis induced by high-LET radiation". United States. doi:10.1667/RR1917.1.
@article{osti_1000434,
title = {Effects of estrogen and gender on cataractogenesis induced by high-LET radiation},
author = {Henderson, M.A. and Rusek, A. and Valluri, S. and Garrett, J. and Lopez, J. and Caperell-Grant, A. and Mendonca, M. and Bigsby, R. and Dynlacht, J.},
abstractNote = {Planning for long-duration manned lunar and interplanetary missions requires an understanding of radiation-induced cataractogenesis. Previously, it was demonstrated that low-linear energy transfer (LET) irradiation with 10 Gy of {sup 60}Co {gamma} rays resulted in an increased incidence of cataracts in male rats compared to female rats. This gender difference was not due to differences in estrogen, since male rats treated with the major secreted estrogen 17-{beta}-estradiol (E2) showed an identical increase compared to untreated males. We now compare the incidence and rate of progression of cataracts induced by high-LET radiation in male and female Sprague-Dawley rats. Rats received a single dose of 1 Gy of 600 MeV {sup 56}Fe ions. Lens opacification was measured at 2-4 week intervals with a slit lamp. The incidence and rate of progression of radiation-induced cataracts was significantly increased in the animals in which estrogen was available from endogenous or exogenous sources. Male rats with E2 capsules implanted had significantly higher rates of progression compared to male rats with empty capsules implanted (P = 0.025) but not compared to the intact female rats. These results contrast with data obtained after low-LET irradiation and suggest the possibility that the different types of damage caused by high- and low-LET radiation may be influenced differentially by steroid sex hormones.},
doi = {10.1667/RR1917.1},
journal = {Radiation Research},
issn = {0033-7587},
number = 2,
volume = 173,
place = {United States},
year = {2010},
month = {2}
}