Johann Deisenhofer, Crystallography, and Proteins

Resources with Additional Information

Johann Deisenhofer
Courtesy of UT Southwestern
Medical Center

"Johann Deisenhofer, Ph.D. is a Professor at UT Southwestern who shared the 1988 Nobel Prize in Chemistry for his research using X-ray crystallography to elucidate for the first time the three-dimensional structure of a large membrane-bound protein molecule.

This structure helped explain the process of photosynthesis, by which sunlight is converted to chemical energy, a process which has been described as the most important chemical reaction on earth. …

Dr. Deisenhofer is a 1974 graduate of the Technical University of Munich. He joined the UT Southwestern faculty in 1988. He is a Regental Professor and holds the Virginia and Edward Linthicum Distinguished Chair in Biomolecular Science."1

Deisenhofer collaborated with DOE scientists on structural biology studies at the Advanced Light Source (ALS) at Lawrence Berkeley National Laboratory (LBNL) and the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). He also used beam lines at the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory (BNL) for a protein structure determination that relied on complementary features of two different beam lines.

1Edited excerpts from Johann Deisenhofer, Ph.D.

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Resources with Additional Information

Additional information about Johann Deisenhofer, crystallography, and proteins is available in electronic documents and on the Web.

Documents:

Structure of the LDL Receptor Extracellular Domain at Endosomal pH; Science, Vol. 298; 2002 [LBNL publication]

Crystal Structure of Cryptochrome 3 from Arabidopsis Thaliana and its Implications for Photolyase Activity; Proceedings of the National Academy of Sciences, Vol. 103 No.47; 2006 [with acknowledgment of APS at ANL]

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol; Cell, Vol. 137 Issue 7; 2009 [with acknowledgment of APS at ANL]

Crystal Structure of Spot 14, a Modulator of Fatty Acid Synthesis; Proceedings of the National Academy of Sciences, Vol. 107 No.44; 2010 [with acknowledgment of APS at ANL]

The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation; PLoS One. 2011; 6(4) 2011. [with acknowledgment of APS at ANL]

Crystal Structure of the Catalytic Portion of Human HMG-CoA Reductase [with acknowledgment of APS at ANL and NSLS at BNL]

Crystal Structure of Bovine Mitochondrial Cytochrome bc1 Complex, An Essential Component of Cellular Power Plant; See pages 2 and 3 [BNL publication]

Structural Basis of Gating by the Outer Membrane Transporter FecA [BNL publication]

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