Use of ceragenins to create novel biofouling resistant water-treatment membranes.

Hibbs, Michael R; Altman, Susan Jeanne; Feng, Yanshu; Savage, Paul B; Pollard, Jacob; Sanchez, Andres L; Fellows, Benjamin D; Jones, Howland D. T.; McGrath, Lucas K

doi:10.2172/946575

Title: Use of ceragenins to create novel biofouling resistant water-treatment membranes.

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Abstract

Scoping studies have demonstrated that ceragenins, when linked to water-treatment membranes have the potential to create biofouling resistant water-treatment membranes. Ceragenins are synthetically produced molecules that mimic antimicrobial peptides. Evidence includes measurements of CSA-13 prohibiting the growth of and killing planktonic Pseudomonas fluorescens. In addition, imaging of biofilms that were in contact of a ceragenin showed more dead cells relative to live cells than in a biofilm that had not been treated with a ceragenin. This work has demonstrated that ceragenins can be attached to polyamide reverse osmosis (RO) membranes, though work needs to improve the uniformity of the attachment. Finally, methods have been developed to use hyperspectral imaging with multivariate curve resolution to view ceragenins attached to the RO membrane. Future work will be conducted to better attach the ceragenin to the RO membranes and more completely test the biocidal effectiveness of the ceragenins on the membranes.

Authors:

Hibbs, Michael R; Altman, Susan Jeanne; Feng, Yanshu ^[1]; Savage, Paul B ^[1]; Pollard, Jacob ^[1]; Sanchez, Andres L ^[2]; Fellows, Benjamin D; Jones, Howland D. T.; McGrath, Lucas K ^[2]

Brigham Young University, Provo, UT
LMATA, Albuquerque, NM

Publication Date:: Mon Dec 01 00:00:00 EST 2008

Research Org.:: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 946575

Report Number(s):: SAND2008-7895
TRN: US200903%%915

DOE Contract Number:: AC04-94AL85000

Resource Type:: Technical Report

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; BIOLOGICAL FOULING; MEMBRANES; OSMOSIS; PEPTIDES; POLYAMIDES; WATER TREATMENT; FUNGICIDES; Membranes (Biology); Biomolecules-Analysis.

Citation Formats


                    Hibbs, Michael R, Altman, Susan Jeanne, Feng, Yanshu, Savage, Paul B, Pollard, Jacob, Sanchez, Andres L, Fellows, Benjamin D, Jones, Howland D. T., and McGrath, Lucas K. Use of ceragenins to create novel biofouling resistant water-treatment membranes..  United States: N. p., 2008. 
        Web.  doi:10.2172/946575.

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                    Hibbs, Michael R, Altman, Susan Jeanne, Feng, Yanshu, Savage, Paul B, Pollard, Jacob, Sanchez, Andres L, Fellows, Benjamin D, Jones, Howland D. T., & McGrath, Lucas K. Use of ceragenins to create novel biofouling resistant water-treatment membranes..  United States.  https://doi.org/10.2172/946575

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                    Hibbs, Michael R, Altman, Susan Jeanne, Feng, Yanshu, Savage, Paul B, Pollard, Jacob, Sanchez, Andres L, Fellows, Benjamin D, Jones, Howland D. T., and McGrath, Lucas K. 2008.  
        "Use of ceragenins to create novel biofouling resistant water-treatment membranes.".  United States.  https://doi.org/10.2172/946575.  https://www.osti.gov/servlets/purl/946575.

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@article{osti_946575,

  title        = {Use of ceragenins to create novel biofouling resistant water-treatment membranes.},

  author       = {Hibbs, Michael R and Altman, Susan Jeanne and Feng, Yanshu and Savage, Paul B and Pollard, Jacob and Sanchez, Andres L and Fellows, Benjamin D and Jones, Howland D. T. and McGrath, Lucas K},

  abstractNote = {Scoping studies have demonstrated that ceragenins, when linked to water-treatment membranes have the potential to create biofouling resistant water-treatment membranes. Ceragenins are synthetically produced molecules that mimic antimicrobial peptides. Evidence includes measurements of CSA-13 prohibiting the growth of and killing planktonic Pseudomonas fluorescens. In addition, imaging of biofilms that were in contact of a ceragenin showed more dead cells relative to live cells than in a biofilm that had not been treated with a ceragenin. This work has demonstrated that ceragenins can be attached to polyamide reverse osmosis (RO) membranes, though work needs to improve the uniformity of the attachment. Finally, methods have been developed to use hyperspectral imaging with multivariate curve resolution to view ceragenins attached to the RO membrane. Future work will be conducted to better attach the ceragenin to the RO membranes and more completely test the biocidal effectiveness of the ceragenins on the membranes.},

  doi          = {10.2172/946575},

  url          = {https://www.osti.gov/biblio/946575},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Dec 01 00:00:00 EST 2008},

  month        = {Mon Dec 01 00:00:00 EST 2008}

}

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