Human Genetic Marker for Resistance to Radiation and Chemicals
Abstract
TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage.
- Authors:
- Publication Date:
- Research Org.:
- The Trustees of Columbia University in The City of New York (US)
- Sponsoring Org.:
- (US)
- OSTI Identifier:
- 789807
- Report Number(s):
- DOE/ER/62309
55100; TRN: US0200645
- DOE Contract Number:
- FG07-96ER62309
- Resource Type:
- Technical Report
- Resource Relation:
- Other Information: PBD: 11 May 2001
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; DNA DAMAGES; GENES; GENETICS; MICE; PROTEINS; IONIZING RADIATIONS; YEASTS; BIOLOGICAL INDICATORS; CHEMICAL WASTES; RADIATIONS; CHEMICALS; HUMAN GENETIC; HAZARDOUS WASTE
Citation Formats
Lieberman, Howard B. Human Genetic Marker for Resistance to Radiation and Chemicals. United States: N. p., 2001.
Web. doi:10.2172/789807.
Lieberman, Howard B. Human Genetic Marker for Resistance to Radiation and Chemicals. United States. https://doi.org/10.2172/789807
Lieberman, Howard B. 2001.
"Human Genetic Marker for Resistance to Radiation and Chemicals". United States. https://doi.org/10.2172/789807. https://www.osti.gov/servlets/purl/789807.
@article{osti_789807,
title = {Human Genetic Marker for Resistance to Radiation and Chemicals},
author = {Lieberman, Howard B},
abstractNote = {TO characterize the human HRDAD9 gene and evaluate its potential as a biomarker to predict susceptibility to the deleterious health effects potentially caused by exposure to radiations or chemicals present at DOE hazardous waste cleanup sites. HRAD9 is a human gene that is highly conserved throughout evolution. Related genes have been isolated from yeasts and mice, underscoring its biological significance. Most of our previous work involved characterization of the yeast gene cognate, wherein it was determined that the corresponding protein plays a significant role in promoting resistance of cells to radiations and chemicals, and in particular, controlling cell growth in response to DNA damage.},
doi = {10.2172/789807},
url = {https://www.osti.gov/biblio/789807},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri May 11 00:00:00 EDT 2001},
month = {Fri May 11 00:00:00 EDT 2001}
}
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