Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake

Knapp, Jr., F. F.; Ambrose, K. R.; Callahan, A. P.; Grigsby, R. A.; Irgolic, K. J.

Title: Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake

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Abstract

These studies were directed at determining if the telluro fatty acids prepared by the isosteric replacement of the ..delta../sup 9/-double bonds of oleic and palmitoleic acids with /sup 123m/Te would show heart uptake in rats. The isostere of palmitoleic acid, 9-tellurapentadecanoic acid(II), was prepared by basic hydrolysis of the product formed by the coupling of /sup 123m/Te-sodium hexyl tellurol with methyl-8-bromooctadecanoate. Similarly, the isostere of oleic acid, 9-telluraheptadecanoic acid(IV), was prepared by the same route beginning with the reaction of /sup 123m/Te-sodium octyl tellurol with methyl-8-bromooctadecanoate. Both /sup 123m/Te-(II) and /sup 123m/Te-(IV) showed remarkably high heart uptake in rats (2 to 3% dose/gm) ten minutes after intravenous administration, and the heart/blood ratios were high (20-30/1). Finally, the hearts of rats injected with /sup 123m/Te-(IV) have been clearly imaged with a rectilinear scanner.

Authors:: Knapp, Jr., F. F.; Ambrose, K. R.; Callahan, A. P.; Grigsby, R. A.; Irgolic, K. J.

Publication Date:: Mon Jan 01 00:00:00 EST 1979

Research Org.:: Oak Ridge National Lab., TN (USA); Texas A and M Univ., College Station (USA). Dept. of Chemistry

Sponsoring Org.:: USDOE Office of Environment, Safety and Health (EH)

OSTI Identifier:: 6298922

Report Number(s):: CONF-790321-3
TRN: 79-010707

DOE Contract Number:: W-7405-ENG-26

Resource Type:: Conference

Resource Relation:: Conference: 2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979

Country of Publication:: United States

Language:: English

Subject:: 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MONOCARBOXYLIC ACIDS; LABELLING; RADIOPHARMACEUTICALS; MYOCARDIUM; SCINTISCANNING; BIOLOGICAL LOCALIZATION; CHEMICAL PREPARATION; TELLURIUM 123; RADIOCHEMISTRY; ISOMERIC NUCLEI; OLEIC ACID; RATS; ANIMALS; BODY; CARBOXYLIC ACIDS; CARDIOVASCULAR SYSTEM; CHEMISTRY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DRUGS; EVEN-ODD NUCLEI; HEART; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MUSCLES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RODENTS; STABLE ISOTOPES; SYNTHESIS; TELLURIUM ISOTOPES; VERTEBRATES; 400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials; 550601 - Medicine- Unsealed Radionuclides in Diagnostics; 560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)

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                    Knapp, Jr., F. F., Ambrose, K. R., Callahan, A. P., Grigsby, R. A., and Irgolic, K. J. Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake.  United States: N. p., 1979. 
        Web.

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                    Knapp, Jr., F. F., Ambrose, K. R., Callahan, A. P., Grigsby, R. A., & Irgolic, K. J. Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake.  United States.

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                    Knapp, Jr., F. F., Ambrose, K. R., Callahan, A. P., Grigsby, R. A., and Irgolic, K. J. 1979.  
        "Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake".  United States.  https://www.osti.gov/servlets/purl/6298922.

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@article{osti_6298922,

  title        = {Tellurium-123m-labeled isosteres of palmitoleic and oleic acids show high myocardial uptake},

  author       = {Knapp, Jr., F. F. and Ambrose, K. R. and Callahan, A. P. and Grigsby, R. A. and Irgolic, K. J.},

  abstractNote = {These studies were directed at determining if the telluro fatty acids prepared by the isosteric replacement of the ..delta../sup 9/-double bonds of oleic and palmitoleic acids with /sup 123m/Te would show heart uptake in rats. The isostere of palmitoleic acid, 9-tellurapentadecanoic acid(II), was prepared by basic hydrolysis of the product formed by the coupling of /sup 123m/Te-sodium hexyl tellurol with methyl-8-bromooctadecanoate. Similarly, the isostere of oleic acid, 9-telluraheptadecanoic acid(IV), was prepared by the same route beginning with the reaction of /sup 123m/Te-sodium octyl tellurol with methyl-8-bromooctadecanoate. Both /sup 123m/Te-(II) and /sup 123m/Te-(IV) showed remarkably high heart uptake in rats (2 to 3% dose/gm) ten minutes after intravenous administration, and the heart/blood ratios were high (20-30/1). Finally, the hearts of rats injected with /sup 123m/Te-(IV) have been clearly imaged with a rectilinear scanner.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/6298922},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Mon Jan 01 00:00:00 EST 1979},

  month        = {Mon Jan 01 00:00:00 EST 1979}

}

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