High-level production of C-11-carboxyl-labeled amino acids. [For use in tumor and pancreatic imaging]
Carbon-11-labeled amino acids have significant potential as agents for positron tomographic functional imaging. We have developed a rapid, high-temperature, high-pressure modification of the Buecherer--Strecker amino acid synthesis and found it to be quite general for the production of C-11-carboxyl-labeled neutral amino acids. Production of C-11-carboxyl-labeled DL-tryptophan requires certain modifications in the procedure. Twelve different amino acids have been produced to date by this technique. Synthesis and chromatographic purification require approximately 40 min, and C-11-carboxyl-labeled amino acids have been produced in yields of up to 425 mCi. Two C-11-carboxyl-labeled amino acids are being investigated clinically for tumor scanning and two others for pancreatic imaging. Over 120 batches of the various agents have been produced for clinical use over a three-year period.
- Research Organization:
- Oak Ridge Associated Universities, Inc., TN (USA). Medical and Health Science Div.; Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- USDOE Office of Environment, Safety and Health (EH)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6298908
- Report Number(s):
- CONF-790321-4; TRN: 79-010708
- Resource Relation:
- Conference: 2. international symposium on radiopharmaceuticals, Seattle, WA, USA, 18 Mar 1979
- Country of Publication:
- United States
- Language:
- English
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Carbon-11-labeled amino acids for the rectilinear and positron tomographic imaging of the human pancreas
Nuclear medicine technology progress report for quarter ending June 30, 1978. ABELLED COMPOUNDS; PATIENTS; POSITRON SOURCES; CARBON 11; ISOMERIC NUCLEI; LABELLED COMPOUNDS; BIOLOGICAL LOCALIZATION; CHEMICAL PREPARATION; ISOMERIC NUCLEI; LABELLED COMPOUNDS; RATS; CHEMICAL PREPARATION; LABELLED COMPOUNDS; RATS; TISSUE DISTRIBUTION
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
LABELLING
CARBON 11
BIOLOGICAL LOCALIZATION
ECAT SCANNING
RADIOCHEMISTRY
NEOPLASMS
DIAGNOSIS
PANCREAS
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARBOXYLIC ACIDS
CAT SCANNING
CHEMISTRY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHOTON EMISSION SCANNING
PHOTON TRANSMISSION SCANNING
RADIOACTIVE MATERIALS
RADIOISOTOPES
SYNTHESIS
TOMOGRAPHY
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics