Boronated porphyrins in NCT: Results with a new potent tumor localizer

Conference · Fri Jan 01 00:00:00 EST 1988

OSTI ID:6172644

Kahl, S B; Koo, M S; Laster, B H; Fairchild, R G

Several chemical methods are available for the solubilization of boronated porphyrins. We have previously reported the tumor localization of nido carboranyl porphyrins in which the icosahedral carborane cages have been opened to give B/sub 9/C/sub 2/ anions. One of these species has shown tumor boron levels of nearly 50 ..mu..g B/g when delivered by week-long subcutaneous infusions. We report here recent in vivo experiments with a new, highly water-soluble porphyrin based on the hematoporphyrin-type of compound in which aqueous solubility is achieved using the two propionic acid side chains of the ''natural'' porphyrin frame. 7 refs.

• Research Organization: Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6172644
• Report Number(s): BNL-42522; CONF-8805150-11; ON: DE89010568
• Resource Relation: Conference: 4. international conference on neutron capture therapy, Bremen, F.R. Germany, 31 May 1988; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEUTRON CAPTURE THERAPY
OPTIMIZATION
ORGANIC BORON COMPOUNDS
SOLUBILITY
PORPHYRINS
EVALUATION
DETECTION
NEOPLASMS
STRUCTURE-ACTIVITY RELATIONSHIPS
TRACER TECHNIQUES
CARBOXYLIC ACIDS
DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
MEDICINE
NEUTRON THERAPY
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOLOGY
RADIOTHERAPY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)