Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine
Abstract
During conventional radiotherapy, the dose that can be delivered to the tumor is limited by the tolerance of the surrounding normal tissue within the treatment volume. Boron Neutron Capture Therapy (BNCT) represents a promising modality for selective tumor irradiation. The key to effective BNCT is selective localization of {sup 10}B in the tumor. We have shown that the synthetic amino acid p-boronophenylalanine (BPA) will selectively deliver boron to melanomas and other tumors such as gliosarcomas and mammary carcinomas. Systemically delivered BPA may have general utility as a boron delivery agent for BNCT. In this paper, BNCT with BPA is used in treatment of experimentally induced gliosarcoma in rats and nonpigmented melanoma in rabbits. The tissue distribution of boron is described, as is response to the BNCT. 6 refs., 4 figs., 1 tab.
- Authors:
-
- Brookhaven National Lab., Upton, NY (USA)
- North Shore Univ. Hospital, Manhasset, NY (USA). Div. of Ophthalmology
- Publication Date:
- Research Org.:
- Brookhaven National Lab., Upton, NY (USA)
- Sponsoring Org.:
- USDOE; USDOE, Washington, DC (USA)
- OSTI Identifier:
- 5643007
- Report Number(s):
- BNL-46148; CONF-901226-4
ON: DE91013808
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Conference
- Resource Relation:
- Conference: 4. international symposium on neutron capture therapy, Sydney (Australia), 3-7 Dec 1990
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; BORON 10; TISSUE DISTRIBUTION; GLIOMAS; NEUTRON CAPTURE THERAPY; MELANOMAS; FEASIBILITY STUDIES; DOSIMETRY; EXPERIMENTAL NEOPLASMS; LABELLED COMPOUNDS; MRR REACTOR; PHENYLALANINE; RABBITS; RATS; SURVIVAL CURVES; AMINO ACIDS; ANIMALS; BORON ISOTOPES; CARBOXYLIC ACIDS; DISEASES; DISTRIBUTION; ENRICHED URANIUM REACTORS; IRRADIATION REACTORS; ISOTOPE PRODUCTION REACTORS; ISOTOPES; LIGHT NUCLEI; MAMMALS; MEDICINE; NEOPLASMS; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOLOGY; RADIOTHERAPY; REACTORS; RESEARCH AND TEST REACTORS; RESEARCH REACTORS; RODENTS; STABLE ISOTOPES; TANK TYPE REACTORS; THERAPY; THERMAL REACTORS; VERTEBRATES; WATER COOLED REACTORS; WATER MODERATED REACTORS; 550603* - Medicine- External Radiation in Therapy- (1980-)
Citation Formats
Coderre, J A, Greenberg, D, Micca, P L, Joel, D D, Saraf, S, and Packer, S. Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine. United States: N. p., 1990.
Web.
Coderre, J A, Greenberg, D, Micca, P L, Joel, D D, Saraf, S, & Packer, S. Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine. United States.
Coderre, J A, Greenberg, D, Micca, P L, Joel, D D, Saraf, S, and Packer, S. 1990.
"Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine". United States. https://www.osti.gov/servlets/purl/5643007.
@article{osti_5643007,
title = {Boron neutron capture therapy of ocular melanoma and intracranial glioma using p-boronophenylalanine},
author = {Coderre, J A and Greenberg, D and Micca, P L and Joel, D D and Saraf, S and Packer, S},
abstractNote = {During conventional radiotherapy, the dose that can be delivered to the tumor is limited by the tolerance of the surrounding normal tissue within the treatment volume. Boron Neutron Capture Therapy (BNCT) represents a promising modality for selective tumor irradiation. The key to effective BNCT is selective localization of {sup 10}B in the tumor. We have shown that the synthetic amino acid p-boronophenylalanine (BPA) will selectively deliver boron to melanomas and other tumors such as gliosarcomas and mammary carcinomas. Systemically delivered BPA may have general utility as a boron delivery agent for BNCT. In this paper, BNCT with BPA is used in treatment of experimentally induced gliosarcoma in rats and nonpigmented melanoma in rabbits. The tissue distribution of boron is described, as is response to the BNCT. 6 refs., 4 figs., 1 tab.},
doi = {},
url = {https://www.osti.gov/biblio/5643007},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}