Effects of chemical carcinogens on the susceptibility of C57BL/10 and (SJL/J x C57BL/10) F/sub 1/ hybrids to Friend leukemia virus

Conference · Tue Jan 01 00:00:00 EST 1980

OSTI ID:5297232

Raikow, R. B.; OKunewick, J. P.; Magliere, K. C.; Brozovich, B. J.; Seeman, P. R.

Under normal circumstances cells of C57BL/10 mice are resistant to infection by Friend leukemia virus (FLV). Pre-treatment by chemical carcinogens does not affect the susceptibility of C57BL/10 mice to FLV leukemogenesis. However, immunosuppression by cyclophosphamide or a congenitally athymic condition allows the replication of the LLV component of FLV to take place in these mice. F1 hybrids between C57BL/10 and SJL/J mice are also resistant to virus, although about twenty percent of these hybrids develop leukemia after massive doses of FLV. Unexpectedly, the F1 hybrid with the virus-sensitive SJL/J mother was more resistant than the F1 hybrid from the reciprocal cross. Pre-treatment of the F1 hybrid or SJL/J mice with chemical carcinogens, such as methyl methane sulfonate and benzo(a)pyrene, but not cyclophosphamide, increased the incidence of leukemia with a peak of increased susceptibility developing at a specific time after treatment. A chemical carcinogen-caused depression of the viability of hematopoietic cells in the spleen, which cells are the major target for FLV oncogenesis, was also temporally related with the increase in susceptibility to the virus. Our data correlated with information on the alleles known to affect resistance to murine leukemia viruses.

• Research Organization: Allegheny-Singer Research Corp., Pittsburgh, PA (USA). Cancer Research Labs.
• DOE Contract Number: AS02-78EV04800
• OSTI ID: 5297232
• Report Number(s): COO-4800-8; CONF-800378-1
• Resource Relation: Conference: Genetic control of natural resistance to infection and malignancy, Montreal, Canada, 18 Mar 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
SENSITIVITY
CARCINOGENS
BIOLOGICAL EFFECTS
ACUTE EXPOSURE
BENZOPYRENE
CELL CULTURES
ERYTHROCYTES
IMMUNITY
LEUKEMIA VIRUSES
LYMPHOCYTES
METHYL METHANESULFONATE
MICE
SPLEEN
STEM CELLS
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
ESTERS
HYDROCARBONS
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
MUTAGENS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PARASITES
RODENTS
SOMATIC CELLS
SULFONIC ACID ESTERS
VERTEBRATES
VIRUSES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)