Modeling and simulation of DNA flow in a microfluidic-based pathogen detection system
We present simulation results from a new computational model of DNA flow in microfluidic devices. This work is important because computational models are needed to design miniaturized biomedical devices that are becoming the state-of-the-art in many significant applications including pathogen detection as well as continuous monitoring and drug delivery. Currently advanced algorithms in design tools are non-existent but necessary to understand the complex fluid and polymer dynamics involved in biological flow at small scales. Our model is based on a fully coupled fluid-particle numerical algorithm with both stochastic and deterministic components in a bead-rod polymer representation. We have applied this work to DNA extraction configurations in a microfluidic PCR chamber used in a pathogen detection system. We demonstrate our method on the test problem of flow of a single DNA molecule in a 2D packed array microchannel. We are also investigating mechanisms for molecular ''sticking'' using short range forces.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 15016241
- Report Number(s):
- UCRL-CONF-209334; TRN: US0502127
- Resource Relation:
- Conference: Presented at: 3rd Annual International IEEE EMBS Special Topic Conference on Microtechnologies in Biomedicine, Oahu, HI (US), 05/12/2005--05/15/2005; Other Information: PDF-FILE: 5 ; SIZE: 0.3 MBYTES; PBD: 31 Jan 2005
- Country of Publication:
- United States
- Language:
- English
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