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Title: Molecular epidemiology of severe ambient air pollution on women and the developing fetus. Progress report, 15 September 1993--14 September 1994

Abstract

The research goal is validation of a number of promising biomarkers in two groups of Polish women and their newborn infants: 73 mother/child pairs from Krakow, a city with elevated air pollution and 90 pairs from Limanowa, a less polluted area. Specifically, the authors are evaluating: (1) the relationship between ambient exposures and the following markers of biologically effective dose and biologic response: PAH-DNA adducts by enzyme-linked immunosorbent assay (ELISA) polycyclic aromatic hydrocarbon-DNA adducts by {sup 32}P-postlabeling and the frequency of gene mutation at the hprt locus in T-lymphocytes; (2) the relationship between markers of biologically effective dose (adducts) and markers of biologic response (gene mutation); (3) the comparison of the same biomarkers in maternal and fetal/newborn tissues to assess possible differences in response and susceptibility; (4) the ability of genetic/metabolic markers (CYP1A1 mRNA, CYP1A1 enzyme activity, CYP1A1 MspI polymorphism and glutathione-S-transferase (GSTM1) genotype) to modify markers of biologically effective dose and biologic response, including an estimate of host versus environmental contributions; and (5) the relationship between biomarkers (PAH-DNA adducts and serum cotinine) to birth weight.

Authors:
Publication Date:
Research Org.:
Columbia Univ., New York, NY (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
10183052
Report Number(s):
DOE/ER/61719-1
ON: DE94018574; BR: KP0302000; TRN: AHC29421%%78
DOE Contract Number:  
FG02-93ER61719
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: [1994]
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; POLAND; AIR POLLUTION; POLYCYCLIC AROMATIC HYDROCARBONS; HEALTH HAZARDS; WOMEN; SENSITIVITY; FETUSES; PROGRESS REPORT; TERATOGENESIS; PHOSPHORUS 32; TRACER TECHNIQUES; MUTAGENESIS; ENZYME IMMUNOASSAY; 540120; 560300; CHEMICALS MONITORING AND TRANSPORT; CHEMICALS METABOLISM AND TOXICOLOGY

Citation Formats

Perera, F P. Molecular epidemiology of severe ambient air pollution on women and the developing fetus. Progress report, 15 September 1993--14 September 1994. United States: N. p., 1994. Web. doi:10.2172/10183052.
Perera, F P. Molecular epidemiology of severe ambient air pollution on women and the developing fetus. Progress report, 15 September 1993--14 September 1994. United States. https://doi.org/10.2172/10183052
Perera, F P. 1994. "Molecular epidemiology of severe ambient air pollution on women and the developing fetus. Progress report, 15 September 1993--14 September 1994". United States. https://doi.org/10.2172/10183052. https://www.osti.gov/servlets/purl/10183052.
@article{osti_10183052,
title = {Molecular epidemiology of severe ambient air pollution on women and the developing fetus. Progress report, 15 September 1993--14 September 1994},
author = {Perera, F P},
abstractNote = {The research goal is validation of a number of promising biomarkers in two groups of Polish women and their newborn infants: 73 mother/child pairs from Krakow, a city with elevated air pollution and 90 pairs from Limanowa, a less polluted area. Specifically, the authors are evaluating: (1) the relationship between ambient exposures and the following markers of biologically effective dose and biologic response: PAH-DNA adducts by enzyme-linked immunosorbent assay (ELISA) polycyclic aromatic hydrocarbon-DNA adducts by {sup 32}P-postlabeling and the frequency of gene mutation at the hprt locus in T-lymphocytes; (2) the relationship between markers of biologically effective dose (adducts) and markers of biologic response (gene mutation); (3) the comparison of the same biomarkers in maternal and fetal/newborn tissues to assess possible differences in response and susceptibility; (4) the ability of genetic/metabolic markers (CYP1A1 mRNA, CYP1A1 enzyme activity, CYP1A1 MspI polymorphism and glutathione-S-transferase (GSTM1) genotype) to modify markers of biologically effective dose and biologic response, including an estimate of host versus environmental contributions; and (5) the relationship between biomarkers (PAH-DNA adducts and serum cotinine) to birth weight.},
doi = {10.2172/10183052},
url = {https://www.osti.gov/biblio/10183052}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Sep 01 00:00:00 EDT 1994},
month = {Thu Sep 01 00:00:00 EDT 1994}
}