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Title: Photoinitiated grafting of porous polymer monoliths and thermoplastic polymers for microfluidic devices

Patent ·
OSTI ID:985414
 [1];  [2];  [3]
  1. Oakland, CA
  2. Alameda, CA
  3. Leiden, NL
+ Show Author Affiliations

A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a porous polymer monolith prepared via UV initiated polymerization within the channel, and functionalization of the pore surface of the monolith using photografting. Processes for making such surface modifications of thermoplastic polymers and porous polymer monoliths are set forth.

Research Organization:
Univ. of California (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC03-76SF00098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Number(s):
7,431,888
Application Number:
10/665,900
OSTI ID:
985414
Country of Publication:
United States
Language:
English

References (28)

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Microfabrication, Microstructures and Microsystems book January 1998
Surface characterization using chemical force microscopy and the flow performance of modified polydimethylsiloxane for microfluidic device applications journal May 2003
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Polymer surface with graft chains journal February 2003
Surface photografting of polymer fibers, films and sheets
  • Rånby, B.; Yang, W. T.; Tretinnikov, O.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 151, Issue 1-4, p. 301-305 https://doi.org/10.1016/S0168-583X(99)00158-5
journal May 1999
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Surface modification of polymeric biomaterials by albumin grafting using γ-irradiation journal July 1994
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Micro Total Analysis Systems. 1. Introduction, Theory, and Technology journal June 2002
Surface modification of poly-L-lactic acid (PLLA) membrane by grafting acrylamide: an effective way to improve cytocompatibility for chondrocytes journal January 2003
Graft copolymer of polyacrylamide and natural rubber produced by means of ultraviolet light journal November 1957
Continuous rods of macroporous polymer as high-performance liquid chromatography separation media journal April 1992
Surface Modification of Poly(dimethylsiloxane) Microfluidic Devices by Ultraviolet Polymer Grafting journal August 2002
Monolithic Porous Polymer for On-Chip Solid-Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device journal November 2001
Fast Ion-Exchange HPLC of Proteins Using Porous Poly(glycidyl methacrylate-co-ethylene dimethacrylate) Monoliths Grafted with Poly(2-acrylamido-2-methyl-1-propanesulfonic acid) journal October 1997
Electrochromatography in Microchips:  Reversed-Phase Separation of Peptides and Amino Acids Using Photopatterned Rigid Polymer Monoliths journal February 2002
Protein patterning by maskless photolithography on hydrophilic polymer-grafted surface journal December 2003
Surface modification of polymers by photoinitiated graft polymerization journal October 1992

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